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Antioxidant genes, which include catalase (\n                    <jats:italic>CAT<\/jats:italic>\n                    ), glutathione peroxidase (\n                    <jats:italic>GPX<\/jats:italic>\n                    ), glutathione\n                    <jats:italic>S<\/jats:italic>\n                    -transferase (\n                    <jats:italic>GST<\/jats:italic>\n                    ), nitric oxide synthase (\n                    <jats:italic>NOS<\/jats:italic>\n                    ), nuclear factor erythroid 2-related factor 2 (\n                    <jats:italic>NRF2<\/jats:italic>\n                    ), and superoxide dismutase (\n                    <jats:italic>SOD<\/jats:italic>\n                    ), play important roles in spermatogenesis and normal sperm function. In this review, we discuss the association between variations in major antioxidant genes and male infertility. Numerous studies have suggested that genetic disruption or functional polymorphisms in these antioxidant genes are associated with a higher risk for male infertility, which include low sperm quality, oligoasthenoteratozoospermia, oligozoospermia, and subfertility. The synergistic effects of environmental ROS and functional polymorphisms on antioxidant genes that result in male infertility have also been reported. Therefore, variants in antioxidant genes, which independently or synergistically occur with environmental ROS, affect spermatogenesis and contribute to the occurrence of male infertility. Large cohort and multiple center-based population studies to identify new antioxidant genetic variants that increase susceptibility to male infertility as well as validate its potential as genetic markers for diagnosis and risk assessment for male infertility for precise clinical approaches are warranted.\n                  <\/jats:p>","DOI":"10.1155\/2015\/513196","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T16:01:47Z","timestamp":1446739307000},"page":"1-10","source":"Crossref","is-referenced-by-count":66,"title":["Variations in Antioxidant Genes and Male Infertility"],"prefix":"10.1155","volume":"2015","author":[{"given":"Bolan","family":"Yu","sequence":"first","affiliation":[{"name":"Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China"},{"name":"Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Third 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