{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:53:59Z","timestamp":1790711639626,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Plasmid-mediated quinolone resistance (PMQR) plays an important role in the development of clinical resistance to quinolone. The aim of this study was to investigate PMQR determinants among extended-spectrum<jats:italic>\u03b2<\/jats:italic>-lactamases- (ESBL-) producing<jats:italic>Klebsiella pneumoniae<\/jats:italic>recovered from patients with nosocomial urinary tract infection (UTI).<jats:italic>Methods<\/jats:italic>. A total of 247 ESBL-producing<jats:italic>K. pneumoniae<\/jats:italic>isolates were collected from 750 patients with UTI. ESBL production was confirmed by double disc synergy test and combined disc diffusion test. The prevalence of PMQR determinants among ESBL-producing<jats:italic>K. pneumoniae<\/jats:italic>was assessed using PCR method.<jats:italic>Results<\/jats:italic>. The rates of resistance to antimicrobial agents in present study varied from 14.2% to 98.8%. In comparison with other PMQR genotypes, the frequency of<jats:italic>aac(6\u2032)-Ib<\/jats:italic>(68.8%) was strikingly high. Of the 247 isolates tested,<jats:italic>qnrA, qnrB, qnrS,<\/jats:italic>and<jats:italic>qepA<\/jats:italic>genes were present in 3.6%, 1.6%, 1.2, and 2%, respectively.<jats:italic>oqxA<\/jats:italic>and<jats:italic>oqxB<\/jats:italic>were detected in 56.7% and 54.6% of isolates. The predominant coexisting ESBL and PMQR profile among our isolates included<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>b<\/mml:mi><mml:mi>l<\/mml:mi><mml:mi>a<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>CTX-M<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>and<jats:italic>aac(6\u2032)-Ib, oqxA, oqxB<\/jats:italic>(28.3%) and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>b<\/mml:mi><mml:mi>l<\/mml:mi><mml:mi>a<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>TEM<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mi>b<\/mml:mi><mml:mi>l<\/mml:mi><mml:mi>a<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>SHV<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>and<jats:italic>aac(6\u2032)-Ib, oqxA,<\/jats:italic>and<jats:italic>oqxB<\/jats:italic>(19.4%) profile.\u2009\u2009<jats:italic>Conclusion<\/jats:italic>. Given the linkage observed between resistance to quinolones and beta lactam antibiotics, therapeutic protocol with fluoroquinolones and beta lactam antibiotics should be seriously revised in Tehran hospitals.<\/jats:p>","DOI":"10.1155\/2015\/518167","type":"journal-article","created":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T21:01:32Z","timestamp":1438549292000},"page":"1-7","source":"Crossref","is-referenced-by-count":24,"title":["Prevalence of Plasmid-Mediated Quinolone Resistance Determinants and OqxAB Efflux Pumps among Extended-Spectrum<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi mathvariant=\"bold-italic\">\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-Lactamase Producing<i>Klebsiella pneumoniae<\/i>Isolated from Patients with Nosocomial Urinary Tract Infection in Tehran, Iran"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-9341","authenticated-orcid":true,"given":"Mehdi","family":"Goudarzi","sequence":"first","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran"},{"name":"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin 1651135779, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima Sadat","family":"Seyedjavadi","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, Pasteur Institute of Iran, Tehran 1316943551, 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