{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:39:37Z","timestamp":1790170777683,"version":"4.1.0"},"reference-count":43,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The purpose of this paper was to evaluate the levels of IL-9 in patients with SLE and RA compared with controls and the association of IL-9 levels with clinical and laboratory parameters. IL-9 levels were assessed in 117 SLE patients, 67 RA patients, and 24 healthy controls by ELISA. Clinical and laboratory parameters were recorded. The IL-9 serum levels were significantly higher in RA patients (4,77 \u00b1 3,618\u2009pg\/mL) and in SLE patients (12,26 \u00b1 25,235\u2009pg\/mL) than in healthy individuals (1,22 \u00b1 0,706\u2009pg\/mL)<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0,001<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. In SLE patients, there were no statistically significant associations or correlations between the levels of IL-9 and SLEDAI or other clinical and laboratorial parameters, with the exception of disease time, which showed a statistically significant negative correlation with IL-9 levels<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn>0,1948<\/mml:mn><mml:mo>;<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0,0378<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. In RA patients, no association or statistically significant correlation was observed with disease duration, DAS28, HAQ, rheumatoid factor positivity, or erosions on radiography. These data demonstrated increased serum levels of IL-9 in SLE and RA patients, but further studies are needed to clarify the precise role of this cytokine and its potential use as therapeutic target.<\/jats:p>","DOI":"10.1155\/2015\/519638","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T21:04:16Z","timestamp":1432069456000},"page":"1-6","source":"Crossref","is-referenced-by-count":45,"title":["Increased Serum Interleukin-9 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Pathogenic Role or Just an Epiphenomenon?"],"prefix":"10.1155","volume":"2015","author":[{"given":"Andr\u00e9a Tavares","family":"Dantas","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisas em Inova\u00e7\u00e3o Terap\u00eautica Suely Galdino (Nupit SG), Universidade Federal de Pernambuco (UFPE), Avenida Professor Moraes Rego, s\/n, 50670-901 Recife, PE, Brazil"},{"name":"Servi\u00e7o de Reumatologia, Hospital das Cl\u00ednicas, UFPE, Avenida Professor Moraes Rego, s\/n, 50670-901 Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Diniz Lopes","family":"Marques","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Reumatologia, Hospital das Cl\u00ednicas, UFPE, Avenida Professor Moraes Rego, s\/n, 50670-901 Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurindo Ferreira","family":"da Rocha Junior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisas em Inova\u00e7\u00e3o Terap\u00eautica Suely Galdino (Nupit SG), Universidade Federal de Pernambuco (UFPE), Avenida Professor Moraes Rego, s\/n, 50670-901 Recife, PE, Brazil"},{"name":"Servi\u00e7o de Reumatologia, Hospital das Cl\u00ednicas, UFPE, Avenida Professor Moraes Rego, s\/n, 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