{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:27:28Z","timestamp":1785824848447,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Orthostatic hypotension (OH) is an important nonmotor manifestation of Parkinson\u2019s disease (PD). Changes in cerebrovascular reactivity may contribute to this manifestation and can be monitored using transcranial Doppler.<jats:italic>Objective<\/jats:italic>. To identify possible changes in cerebrovascular reactivity in patients with OH.<jats:italic>Methods<\/jats:italic>. Twenty-two individuals were selected and divided into three groups: with and without OH and controls. Transcranial Doppler was used to assess basal mean blood flow velocity, postapnea mean blood flow velocity, percentage increase in mean blood flow velocity, and cerebrovascular reactivity as measured by the breath-holding index.<jats:italic>Results<\/jats:italic>. PD patients had lower values of basal velocity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.019<\/mml:mn><\/mml:math>), postapnea velocity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0015<\/mml:mn><\/mml:math>), percentage increase in velocity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.039<\/mml:mn><\/mml:math>), and breath-holding index (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>) than the controls. Patients with OH had higher values of basal velocity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.09<\/mml:mn><\/mml:math>) and postapnea velocity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.19<\/mml:mn><\/mml:math>) but lower values of percentage increase in velocity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.22<\/mml:mn><\/mml:math>) and breath-holding index (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.32<\/mml:mn><\/mml:math>) than patients without OH.<jats:italic>Conclusions<\/jats:italic>. PD patients present with abnormalities in a compensatory mechanism that regulates cerebral blood flow. OH could be an indicator of these abnormalities.<\/jats:p>","DOI":"10.1155\/2015\/523041","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T17:02:52Z","timestamp":1434474172000},"page":"1-5","source":"Crossref","is-referenced-by-count":12,"title":["Abnormal Cerebrovascular Reactivity in Patients with Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Carlos Henrique Ferreira","family":"Camargo","sequence":"first","affiliation":[{"name":"State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Antunes","family":"Martins","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Christiano","family":"Lange","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas, Federal University of Paran\u00e1, Rua General Carneiro 181, 80060-900 Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Alvaro","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jissa Jeanete","family":"Luciano","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Rezende","family":"Young Blood","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Derbli","family":"Schafranski","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Machado","family":"Ferro","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmar","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.17.5.427"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-002-0808-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050508"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.04.011"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.029413"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.05.020"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00155-U"},{"key":"8","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.3949\/ccjm.74.Suppl_1.S91","volume":"74","year":"2007","journal-title":"Cleveland Clinic Journal of Medicine"},{"issue":"11","key":"9","first-page":"1775","volume":"46","year":"2005","journal-title":"Journal of Nuclear Medicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.02.033"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.12.017"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.11.028"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/629378"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.230425"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2011.01591.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.23.5.668"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/s0950-821x(05)80795-9"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-006-0317-8"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0460.1000155"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.s53983"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/s1353-8020(01)00014-1"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/s1353-8020(03)00069-5"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.12.014"},{"issue":"2","key":"24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.parkreldis.2008.03.007","volume":"15","year":"2009","journal-title":"Parkinsonism and Related Disorders"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2004.06.009"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2010.06.016"}],"container-title":["Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/523041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/523041.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/523041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T09:52:07Z","timestamp":1498211527000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/pd\/2015\/523041\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":26,"alternative-id":["523041","523041"],"URL":"https:\/\/doi.org\/10.1155\/2015\/523041","relation":{},"ISSN":["2090-8083","2042-0080"],"issn-type":[{"value":"2090-8083","type":"print"},{"value":"2042-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}