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However, the action of<jats:italic>Plumula Nelumbinis<\/jats:italic>on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of<jats:italic>Plumula Nelumbinis<\/jats:italic>(CEPN) was prepared, which completely inhibited precontraction induced by high K<jats:sup>+<\/jats:sup>in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca<jats:sup>2+<\/jats:sup>channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca<jats:sup>2+<\/jats:sup>influx, resulting in relaxation of precontracted ASM. 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