{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:09:20Z","timestamp":1788977360345,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"FONCYT PICT","award":["2011-1846"],"award-info":[{"award-number":["2011-1846"]}]},{"name":"FONCYT PICT","award":["PIP 112-200801-01455"],"award-info":[{"award-number":["PIP 112-200801-01455"]}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","award":["2011-1846"],"award-info":[{"award-number":["2011-1846"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","award":["PIP 112-200801-01455"],"award-info":[{"award-number":["PIP 112-200801-01455"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SECYT-UNC","award":["2011-1846"],"award-info":[{"award-number":["2011-1846"]}]},{"name":"SECYT-UNC","award":["PIP 112-200801-01455"],"award-info":[{"award-number":["PIP 112-200801-01455"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the first time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O<jats:sub>3<\/jats:sub>levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables\/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.<\/jats:p>","DOI":"10.1155\/2015\/527835","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T21:04:13Z","timestamp":1442437453000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Climatic Droplet Keratopathy in Argentina: Involvement of Environmental Agents in Its Genesis Which Would Open the Prospect for New Therapeutic Interventions"],"prefix":"10.1155","volume":"2015","author":[{"given":"Mar\u00eda Fernanda","family":"Su\u00e1rez","sequence":"first","affiliation":[{"name":"CIBICI-CONICET, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Haya de la Torre esquina Medina Allende, 5000 C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Correa","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Clinica Universitaria Reina Fabiola, Universidad Cat\u00f3lica de C\u00f3rdoba, Oncativo 1248, 5000 C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Crim","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Clinica Universitaria Reina Fabiola, Universidad Cat\u00f3lica de C\u00f3rdoba, Oncativo 1248, 5000 C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelina","family":"Esp\u00f3sito","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Clinica Universitaria Reina Fabiola, Universidad Cat\u00f3lica de C\u00f3rdoba, Oncativo 1248, 5000 C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Monti","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Clinica Universitaria Reina Fabiola, Universidad Cat\u00f3lica de C\u00f3rdoba, Oncativo 1248, 5000 C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Alberto","family":"Urrets-Zaval\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Clinica Universitaria Reina Fabiola, Universidad Cat\u00f3lica de C\u00f3rdoba, Oncativo 1248, 5000 C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio Marcelo","family":"Serra","sequence":"additional","affiliation":[{"name":"CIBICI-CONICET, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Haya de la Torre esquina Medina Allende, 5000 C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/bf01948820"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1973.01000040195006"},{"issue":"4","key":"3","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1755-3768.1972.tb05980.x","volume":"50","year":"1972","journal-title":"Acta Ophthalmologica"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(92)90093-9"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1755-3768.1974.tb01114.x","volume":"52","year":"1974","journal-title":"Acta Ophthalmologica"},{"key":"6","first-page":"618","volume-title":"Degenerations, depositions, and miscellaneous reactions of the ocular anterior segment","year":"2008"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/BF01854783"},{"key":"8","first-page":"387","volume":"18","year":"1937","journal-title":"Archivio Italiano di Scienze Mediche Coloniali"},{"issue":"3","key":"9","first-page":"293","volume":"27","year":"1967","journal-title":"Medecine Tropicale"},{"key":"10","first-page":"471","volume":"31","year":"1954","journal-title":"East African Medical Journal"},{"key":"11","first-page":"101","volume":"68","year":"1955","journal-title":"Bulletins et M\u00e9moires de la Soci\u00e9t\u00e9 Fran\u00e7aise d'Ophtalmologie"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.57.9.657"},{"key":"13","first-page":"316","volume":"190","year":"1957","journal-title":"Annales d'Oculistique"},{"key":"14","first-page":"129","volume":"41","year":"1962","journal-title":"Bollettino di Oculistica"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(64)92222-6"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1965.00970040200013"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(75)90470-5"},{"key":"18","first-page":"9","volume":"7","year":"1970","journal-title":"Archaeology and Anthropology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(72)91202-0"},{"issue":"2","key":"20","first-page":"327","volume":"67","year":"1972","journal-title":"The American Journal of Pathology"},{"issue":"22","key":"21","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.5694\/j.1326-5377.1972.tb47545.x","volume":"2","year":"1972","journal-title":"Medical Journal of Australia"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.3.154"},{"issue":"2","key":"23","first-page":"280","volume":"8","year":"1973","journal-title":"Canadian Journal of Ophthalmology"},{"issue":"2","key":"24","first-page":"298","volume":"8","year":"1973","journal-title":"Canadian Journal of Ophthalmology"},{"issue":"2","key":"25","first-page":"95","volume":"18","year":"1975","journal-title":"Papua and New Guinea Medical Journal"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.4.256"},{"issue":"4","key":"27","first-page":"72","volume":"79","year":"1976","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"28","first-page":"364","volume-title":"Pterygium, climatic keratopathy and pinguecula of the eyes in Arctic and subarctic populations","year":"1976"},{"issue":"1","key":"29","first-page":"10","volume":"98","year":"1978","journal-title":"Transactions of the Ophthalmological Societies of the United Kingdom"},{"issue":"4","key":"30","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1755-3768.1978.tb01368.x","volume":"56","year":"1978","journal-title":"Acta Ophthalmologica"},{"issue":"11","key":"31","first-page":"733","volume":"11","year":"1988","journal-title":"Journal Fran\u00e7ais d'Ophtalmologie"},{"key":"32","first-page":"103","volume":"84","year":"1985","journal-title":"Circumpolar Health"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.3109\/09286589509057090"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.10.044"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31806bef31"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1973.01000040200007"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.62.1.53"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.79"},{"issue":"4","key":"39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00004397-198602640-00006","volume":"26","year":"1986","journal-title":"International Ophthalmology Clinics"},{"key":"40","first-page":"147","volume":"3","year":"1988","journal-title":"Saudi Journal of Ophthalmology"},{"issue":"1","key":"41","first-page":"1","volume":"6","year":"2000","journal-title":"Molecular Vision"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1284"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900329"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.099812"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.04.053"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.06.002"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1021\/pr800962q"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01764.x"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9441"},{"key":"50","first-page":"525","volume":"41","year":"2007","journal-title":"Acta Bioqu\u00edmica Cl\u00ednica Latinoamericana"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12628"},{"key":"52","first-page":"49","volume":"42","year":"2011","journal-title":"Archivos Argentinos de Alergia e Inmunolog\u00eda Cl\u00ednica"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074593"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070020555039"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e318223394e"},{"issue":"2","key":"56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1034\/j.1600-0420.1998.760205.x","volume":"76","year":"1998","journal-title":"Acta Ophthalmologica Scandinavica"},{"issue":"7","key":"57","first-page":"1681","volume":"41","year":"2000","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1929"},{"key":"59","first-page":"311","volume-title":"Vitamin C functions in the cornea: ultra-structural features in ascorbate deficiency","year":"2014"},{"issue":"13","key":"60","first-page":"3130","volume":"42","year":"2001","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1159\/000081208"},{"key":"62","first-page":"3107","volume":"17","year":"2011","journal-title":"Molecular Vision"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00742-2"},{"issue":"3","key":"64","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3928\/1081-597X-20030501-11","volume":"19","year":"2003","journal-title":"Journal of Refractive Surgery"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080130101035"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1562\/2005-03-02-RA-452R.1"},{"key":"67","volume":"51","year":"2010","journal-title":"Investigative Ophthalmology & Visual Science"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/527835.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/527835.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/527835.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T05:24:33Z","timestamp":1718083473000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/527835\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":67,"alternative-id":["527835","527835"],"URL":"https:\/\/doi.org\/10.1155\/2015\/527835","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}