{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:46:58Z","timestamp":1767962818805,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Burkholderia<\/jats:italic>(formerly<jats:italic>Pseudomonas<\/jats:italic>)<jats:italic>cepacia<\/jats:italic>complex is a known serious threat to patients with cystic fibrosis, in whom it has the potential to cause the fatal combination of necrotizing pneumonia, worsening respiratory failure, and bacteremia, known as Cepacia syndrome. The potential for this pathogen to infect non-cystic fibrosis patients is limited and its epidemiology is poorly understood. Previously reported cases of severe<jats:italic>Burkholderia cepacia<\/jats:italic>complex lung infection in immunocompetent hosts include pneumonia, bronchiectasis, pyopneumothorax, and cavitary lesions. We present a case of a 64-year-old man with<jats:italic>Streptococcus pneumoniae<\/jats:italic>community-acquired pneumonia whose hospital course was complicated by developing cavitary lung lesions, bacteremia, and acute respiratory distress syndrome. Repeated tracheal aspirate and blood cultures grew<jats:italic>Burkholderia cepacia<\/jats:italic>. Our case appears to be the first report of Cepacia syndrome in a patient without cystic fibrosis. This report raises concern regarding the potential severity of pulmonary<jats:italic>Burkholderia cepacia<\/jats:italic>complex infection and the need to broaden clinicians\u2019 suspicion for Cepacia syndrome. A framework to help diagnose and treat infected non-cystic fibrosis individuals may be useful.<\/jats:p>","DOI":"10.1155\/2015\/537627","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T17:03:00Z","timestamp":1439917380000},"page":"1-4","source":"Crossref","is-referenced-by-count":9,"title":["Cepacia Syndrome in a Non-Cystic Fibrosis Patient"],"prefix":"10.1155","volume":"2015","author":[{"given":"Naomi","family":"Hauser","sequence":"first","affiliation":[{"name":"Department of Medicine, New York University School of Medicine, Woodhull Medical and Mental Health Center, Brooklyn, NY 11206, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-3180","authenticated-orcid":true,"given":"Jose","family":"Orsini","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine, Woodhull Medical and Mental Health Center, Brooklyn, NY 11206, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0402.980209"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.43.6.2926-2928.2005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2008.02.005"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.08.2010.3296"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.04.002"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2004.03.007"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.5.430"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1086\/519177"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1155\/2003\/675159","volume":"14","year":"2003","journal-title":"Canadian Journal of Infectious Diseases"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-45-6-395"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.04.002"},{"issue":"4","key":"12","first-page":"363","volume":"134","year":"1986","journal-title":"Canadian Medical Association Journal"},{"issue":"1","key":"13","first-page":"15","volume":"119","year":"1973","journal-title":"California Medicine"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.6.1842"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/s2221-1691(11)60215-3"},{"issue":"2","key":"16","first-page":"100","volume":"3","year":"2013","journal-title":"Nitte University Journal of Health Science"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.5.887"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880060"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1086\/314699"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17202950"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1086\/501927"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.07.016"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2015\/537627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2015\/537627.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2015\/537627.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T13:52:28Z","timestamp":1498225948000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criid\/2015\/537627\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":22,"alternative-id":["537627","537627"],"URL":"https:\/\/doi.org\/10.1155\/2015\/537627","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}