{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:33Z","timestamp":1740169773507,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"],"award-info":[{"award-number":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"],"award-info":[{"award-number":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Provincial Cultivation Program for Leaders of Disciplines in Science","award":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"],"award-info":[{"award-number":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"]}]},{"name":"Innovative Research Team Program in Education Department of Sichuan Province","award":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"],"award-info":[{"award-number":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"]}]},{"name":"Innovative Research Team Program in Education Department of Sichuan Province","award":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"],"award-info":[{"award-number":["31201891","20125103120012","2012JQ0040","12TD005","2013TD0015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Interferon<jats:italic>\u03b3<\/jats:italic>receptor 1 (IFNGR1) and IFNGR2 are two cell membrane molecules belonging to class II cytokines, which play important roles in the IFN-mediated antiviral signaling pathway. Here, goose IFNGR1 and IFNGR2 were cloned and identified for the first time. Tissue distribution analysis revealed that relatively high levels of goose IFN<jats:italic>\u03b3<\/jats:italic>mRNA transcripts were detected in immune tissues, including the harderian gland, cecal tonsil, cecum, and thymus. Relatively high expression levels of both IFNGR1 and IFNGR2 were detected in the cecal tonsil, which implicated an important role of IFN<jats:italic>\u03b3<\/jats:italic>in the secondary immune system of geese. No specific correlation between IFN<jats:italic>\u03b3<\/jats:italic>, IFNGR1, and IFNGR2 expression levels was observed in the same tissues of healthy geese. IFN<jats:italic>\u03b3<\/jats:italic>and its cognate receptors showed different expression profiles, although they appeared to maintain a relatively balanced state. Furthermore, the agonist R848 led to the upregulation of goose IFN<jats:italic>\u03b3<\/jats:italic>but did not affect the expression of goose IFNGR1 or IFNGR2. In summary, trends in expression of goose IFN<jats:italic>\u03b3<\/jats:italic>and its cognate receptors showed tissue specificity, as well as an age-related dependency. These findings may help us to better understand the age-related susceptibility to pathogens in birds.<\/jats:p>","DOI":"10.1155\/2015\/537637","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T17:09:04Z","timestamp":1438880944000},"page":"1-14","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Type II Interferon Receptors in Geese: Gene Structure, Phylogenetic Analysis, and Expression Patterns"],"prefix":"10.1155","volume":"2015","author":[{"given":"Hao","family":"Zhou","sequence":"first","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Qi","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingshu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renyong","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dekang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mafeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anchun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan 611130, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0603252"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.11.021"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.563"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1126\/science.8197455"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.003035"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.11.002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2007.0135"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2006.26.441"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2012.02.008"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-305X(02)00076-9"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151121045"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-012-1601-7"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msm092"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.749"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00204.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(02)00036-9"},{"key":"17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-2776(07)96002-2","volume":"96","year":"2007","journal-title":"Advances in Immunology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s1471-4906(01)02005-1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(00)00199-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2307\/1592155"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/86.7.1351"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2010.07.001"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.03.008"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2009.06.002"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1172\/jci113938"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910360116"},{"issue":"1","key":"27","first-page":"16","volume":"123","year":"1986","journal-title":"The American Journal of Pathology"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/537637.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/537637.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/537637.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T13:08:44Z","timestamp":1498223324000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/537637\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":27,"alternative-id":["537637","537637"],"URL":"https:\/\/doi.org\/10.1155\/2015\/537637","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2015]]}}}