{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:16:15Z","timestamp":1764587775716,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Key Medical Professional Development Plan of Beijing Municipal Administration of Hospitals","award":["ZY201301","D111107003111009","30830045","201206006"],"award-info":[{"award-number":["ZY201301","D111107003111009","30830045","201206006"]}]},{"name":"Major Project of the Science and Technology Plan of the Beijing Municipal Science & Technology Commission","award":["ZY201301","D111107003111009","30830045","201206006"],"award-info":[{"award-number":["ZY201301","D111107003111009","30830045","201206006"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZY201301","D111107003111009","30830045","201206006"],"award-info":[{"award-number":["ZY201301","D111107003111009","30830045","201206006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kallikrein Medical Research Program","award":["ZY201301","D111107003111009","30830045","201206006"],"award-info":[{"award-number":["ZY201301","D111107003111009","30830045","201206006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Conventional two-dimensional vessel wall imaging has been used to depict the middle cerebral artery (MCA) wall in patients with recent small subcortical infarctions (RSSIs). However, its clinical use has been limited by restricted spatial coverage, low signal-to-noise ratio (SNR), and long scan time. We used a novel three-dimensional high-resolution MR imaging (3D HR-MRI) technique to investigate the presence, locations, and contrast-enhanced patterns of MCA plaques and their relationship with RSSI.<jats:italic>Methods<\/jats:italic>. Nineteen consecutive patients with RSSI but no luminal stenosis on MR angiography were prospectively enrolled. 3D HR-MRI was performed using a T1w-SPACE sequence at 3.0\u2009T. The presence, locations, and contrast-enhanced patterns of the MCA plaques on the ipsilateral and contralateral sides to the RSSI were analyzed.<jats:italic>Results<\/jats:italic>. Eighteen patients successfully completed the study. MCA atherosclerotic plaques occurred more frequently on the ipsilateral than the contralateral side to the RSSI (72.2% versus 33.3%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.044<\/mml:mn><\/mml:math>). The occurrence of superiorly located plaques was significantly higher on the ipsilateral than the contralateral side of the MCA (66.7% versus 27.8%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.044<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Superiorly located plaques are closely associated with RSSI. 3D high-resolution vessel wall imaging may be a potential tool for etiologic assessment of ischemic stroke.<\/jats:p>","DOI":"10.1155\/2015\/540217","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T19:15:54Z","timestamp":1444677354000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["Middle Cerebral Artery Atherosclerotic Plaques in Recent Small Subcortical Infarction: A Three-Dimensional High-resolution MR Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Xiao-Dong","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiu-Cho","family":"Chung","sequence":"additional","affiliation":[{"name":"Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China"},{"name":"Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China"},{"name":"Neurodegenerative Laboratory of Ministry of Education of the People\u2019s Republic of China, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China"},{"name":"Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China"},{"name":"Neurodegenerative Laboratory of Ministry of Education of the People\u2019s Republic of China, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.5.652"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.15.8.774"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685305"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050584"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.583534"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12224"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1159\/000341399"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.113.001467"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22592"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(13)70124-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21386"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22049"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.06.006"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.50.6.1699"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.2.0151"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.2.0261"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24222"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/hc0802.104327"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.06.035"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21758"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.63.2.0266"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.24.1.35"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20617"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2011.00006"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.618132"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500380035003"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.112.662692"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.12.029"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3209"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a3606"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122812"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000225074.47396.71"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/540217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/540217.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/540217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T17:08:37Z","timestamp":1471540117000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/540217\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":32,"alternative-id":["540217","540217"],"URL":"https:\/\/doi.org\/10.1155\/2015\/540217","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2015]]}}}