{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:26Z","timestamp":1740169766574,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-Sen University","doi-asserted-by":"publisher","award":["900033283407","31070806"],"award-info":[{"award-number":["900033283407","31070806"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["900033283407","31070806"],"award-info":[{"award-number":["900033283407","31070806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To assess the serum vitamin D and ICTP levels in patients with ankylosing spondylitis (AS) and investigate their relationship with disease activity and bone mineral density (BMD).<jats:italic>Method<\/jats:italic>. 150 patients and 168 controls were included. Serum 25(OH)D, ICTP, C-reaction protein (CRP), Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), and Hip BMD were assessed in patients. 25(OH)D and ICTP were detected in controls.<jats:italic>Results<\/jats:italic>. The serum 25(OH)D in AS was 57.92 \u00b1 24.42\u2009nmol\/L, significantly lower than controls (91.24 \u00b1 42.02\u2009nmol\/L). Serum ICTP in AS was 5.72 \u00b1 3.88\u2009ug\/L, significantly higher than controls (3.69 \u00b1 1.26\u2009ug\/L). ICTP level was higher in men than in women patients (6.07 \u00b1 4.05 versus 3.84 \u00b1 1.96\u2009ug\/L,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>); it was also higher in JAS than in AAS (9.52 \u00b1 3.79 versus 5.27 \u00b1 3.65\u2009ug\/L,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). Furthermore, 25(OH)D was negatively correlated with ICTP. Low 25(OH)D and high ICTP were one of the reasons of AS patients\u2019 low hip BMD. Besides, a significant relationship was found between serum ICTP and CRP.<jats:italic>Conclusion<\/jats:italic>. There was a high incidence of vitamin D inadequacy in AS. Serum ICTP level was elevated in AS, especially in JAS and male patients. 25(OH)D and ICTP seem to be valuable markers to detect bone loss in AS.<\/jats:p>","DOI":"10.1155\/2015\/543806","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T03:16:08Z","timestamp":1437966968000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Serum Vitamin D and Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Pingping","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiujing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zetao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linkai","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Third 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