{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:28:30Z","timestamp":1761823710338,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis.<jats:italic>Case Report<\/jats:italic>. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma.<jats:italic>Discussion<\/jats:italic>. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.<\/jats:p>","DOI":"10.1155\/2015\/545603","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T16:01:32Z","timestamp":1423065692000},"page":"1-5","source":"Crossref","is-referenced-by-count":8,"title":["Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Catarina","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital de Braga, Sete Fontes, S\u00e3o Victor, 4710-243 Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7825-8154","authenticated-orcid":true,"given":"Cristina","family":"Resende","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital de Braga, Sete Fontes, S\u00e3o Victor, 4710-243 Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Pardal","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Department, Hospital de Braga, Sete Fontes, S\u00e3o Victor, 4710-243 Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste","family":"Brito","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital de Braga, Sete Fontes, S\u00e3o Victor, 4710-243 Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000175532.27368.3f"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(02)00030-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02385.x"},{"issue":"1","key":"4","first-page":"52","volume":"13","year":"2001","journal-title":"Clinical Oncology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.4.0782"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.39.207.508"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(96)90674-x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1159\/000085167"},{"issue":"5","key":"9","first-page":"859","volume":"15","year":"1994","journal-title":"The American Journal of Neuroradiology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(05)83168-3"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.1970.tb02362.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200104010-00005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70115-i"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00560.x"},{"key":"15","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/(SICI)1097-0142(19990901)86:5<878::AID-CNCR26>3.0.CO;2-Y","volume":"86","year":"1999","journal-title":"Cancer"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1956.tb04718.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.022"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06316.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(94)70204-7"},{"issue":"1, supplement","key":"20","first-page":"96","volume":"102","year":"2005","journal-title":"Journal of Neurosurgery"},{"issue":"1","key":"21","first-page":"138","volume":"25","year":"2004","journal-title":"The American Journal of Neuroradiology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.165.1.3628773"},{"issue":"2","key":"23","first-page":"380","volume":"12","year":"1991","journal-title":"American Journal of Neuroradiology"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2015\/545603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2015\/545603.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2015\/545603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:58:37Z","timestamp":1498179517000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crim\/2015\/545603\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"alternative-id":["545603","545603"],"URL":"https:\/\/doi.org\/10.1155\/2015\/545603","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"type":"print","value":"1687-9627"},{"type":"electronic","value":"1687-9635"}],"subject":[],"published":{"date-parts":[[2015]]}}}