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Helminth parasites have developed immunomodulatory strategies that may impact the outcome of several inflammatory diseases. Therefore, we investigated whether<jats:italic>Taenia crassiceps<\/jats:italic>infection is able to decrease the inflammatory effects of dextran sulfate sodium- (DSS-) induced ulcerative colitis in BALB\/c and C57BL\/6 mice. Preinfection significantly reduced the manifestations of DSS-induced colitis, as weight loss and shortened colon length, and decreased the disease activity index independently of the genetic background of the mice.<jats:italic>Taenia<\/jats:italic>infection decreased systemic levels of proinflammatory cytokines while increasing levels of IL-4 and IL-10, and the inflammatory infiltrate into the colon was also markedly reduced. RT-PCR assays from colon showed that<jats:italic>T. crassiceps<\/jats:italic>-infected mice displayed increased expression of Arginase-1 but decreased expression of iNOS compared to DSS-treated uninfected mice. The percentages of T regulatory cells were not increased. The adoptive transfer of alternatively activated macrophages (AAM<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u0424<\/mml:mi><\/mml:mrow><\/mml:math>s) from infected mice into mice with DSS-induced colitis reduced the severity of colon inflammation. Administration of indomethacin abrogated the anticolitic effect of<jats:italic>Taenia<\/jats:italic>. Thus,<jats:italic>T. crassiceps<\/jats:italic>infection limits the pathology of ulcerative colitis by suppressing inflammatory responses mechanistically associated with AAM<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u0424<\/mml:mi><\/mml:mrow><\/mml:math>s and prostaglandins.<\/jats:p>","DOI":"10.1155\/2015\/563425","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T23:27:06Z","timestamp":1431991626000},"page":"1-17","source":"Crossref","is-referenced-by-count":35,"title":["Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yadira","family":"Ledesma-Soto","sequence":"first","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de 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