{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:29:51Z","timestamp":1788985791471,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":105,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81030058"],"award-info":[{"award-number":["81030058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401338"],"award-info":[{"award-number":["81401338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81030058"],"award-info":[{"award-number":["81030058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401338"],"award-info":[{"award-number":["81401338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. CD161 has been identified as a marker of human IL\u201017\u2010producing T cells that are implicated in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the potential link between the percentage of CD161+ T cells and disease activity in RA patients. <jats:italic>Methods<\/jats:italic>. Peripheral blood (PB) from 54 RA patients and 21 healthy controls was evaluated. Paired synovial fluid (SF) (<jats:italic>n<\/jats:italic> = 17) was analyzed. CD161 expression levels on CD4+, CD8+, and CD4\u2212CD8\u2212 T cells were assessed by flow cytometry. <jats:italic>Results<\/jats:italic>. The percentage of CD4+CD161+ T cells in RA SF was higher than RA PB, and it was positively correlated with DAS28, erythrocyte sedimentation rate (ESR), and C\u2010reactive protein (CRP). CD4\u2212CD8\u2212CD161+ T cell percentage was decreased in RA PB and was further reduced in RA SF, and its level in SF was inversely correlated with DAS28, ESR, and CRP. However, CD8+CD161+ T cell percentage was neither changed in RA PB and SF nor correlated with disease activity indices. <jats:italic>Conclusion<\/jats:italic>. An increased CD4+CD161+ T cell percentage and a decreased CD4\u2212CD8\u2212CD161+ T cell percentage are present in RA SF and are associated with disease activity, and the accumulation of CD4+CD161+ T cells in SF may contribute to the local inflammation of RA.<\/jats:p>","DOI":"10.1155\/2015\/563713","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:09:09Z","timestamp":1429229349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Percentages of CD4+CD161+ and CD4\u2212CD8\u2212CD161+ T Cells in the Synovial Fluid Are Correlated with Disease Activity in Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Jinlin","family":"Miao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1004965"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.80"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24568"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3431"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.846407"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2010.02.006"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-013119990542:5hssmx0003C;963::aid-anr15hssmx003E;3.0.co;2-e"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21749"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2832"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001107"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.6.2417"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080397"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940257"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079370"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.854070"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081712"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270932"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079370"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330903"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel119"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901533"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8761"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201511"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/563713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/563713.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2015\/563713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:40:29Z","timestamp":1722894029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/563713"}},"subtitle":[],"editor":[{"given":"Lifei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1155\/2015\/563713"],"URL":"https:\/\/doi.org\/10.1155\/2015\/563713","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2014-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"563713"}}