{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:12:01Z","timestamp":1781583121074,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>CRP is a plasma protein that reflects a measure of the acute phase response to inflammation and is one of the markers of choice in monitoring this response. CRP can be used for the prediction and early detection of periodontal disease. The aim of this study was to compare and evaluate the systemic levels of CRP in the peripheral blood samples of patients with chronic and aggressive periodontitis, gingivitis, and gingival recessions and compare them with periodontal clinical parameters. All patients (<jats:italic>N<\/jats:italic> = 158) were examined prior to the initiation of periodontal treatment. Patients were divided into four groups. Group A consisted of 26 patients with aggressive periodontitis, Group B consisted of 111 patients with chronic periodontitis, Group C consisted of 13 patients with gingivitis, and Group D consisted of 8 patients with gingival recessions. Our study results indicate that CRP levels increase subsequently with the severity of the periodontal disease and that the bleeding on probing index showed much better positive correlation with the CRP levels compared to the pocket depth index in both periodontitis patients groups, especially in aggressive periodontitis patients.<\/jats:p>","DOI":"10.1155\/2015\/564858","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T06:28:29Z","timestamp":1438756109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["C\u2010Reactive Protein in Peripheral Blood of Patients with Chronic and Aggressive Periodontitis, Gingivitis, and Gingival Recessions"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-2671","authenticated-orcid":false,"given":"Stepan","family":"Podzimek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-4799","authenticated-orcid":false,"given":"Jaroslav","family":"Mysak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Janatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-173X","authenticated-orcid":false,"given":"Jana","family":"Duskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.52.4.561"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.100318"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.r400025200"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100511"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100334"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2014\/8355.4646"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237x.142816"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01288.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12076"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124x.138688"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1626.2010.00022.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080561"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.137390"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2013.15.92.2326"},{"key":"e_1_2_8_15_2","first-page":"145","article-title":"Effect of non-surgical periodontal therapy on serum levels of TNF-a, IL-6 and C-reactive protein in periodontitis subjects with stable coronary heart disease","volume":"16","author":"Zhou S. Y.","year":"2013","journal-title":"The Chinese Journal of Dental Research"},{"key":"e_1_2_8_16_2","first-page":"24","article-title":"Effect of intensive non-surgical treatment on the level of serum inflammatory markers in advanced periodontitis","volume":"7","author":"Radafshar G.","year":"2010","journal-title":"Journal of Dentistry"},{"key":"e_1_2_8_17_2","first-page":"151","article-title":"C-reactive protein levels in patients with periodontal disease and normal subjects","volume":"2","author":"Shojaee M.","year":"2013","journal-title":"International Journal of Molecular and Cellular Medicine"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124x.147410"},{"key":"e_1_2_8_19_2","unstructured":"American Academy of Periodontology http:\/\/www.perio.org\/."},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1997.tb00492.x"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-011-0627-7"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050165"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.4103\/2141-9248.133465"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(93)90114-K"},{"key":"e_1_2_8_26_2","volume-title":"Carranza\u2019s Clinical Periodontology","author":"Newman M.","year":"2012"},{"key":"e_1_2_8_27_2","volume-title":"Preclinical Periodontology","author":"Slezak R.","year":"2007"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1995.tb00035.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01140.x"},{"key":"e_1_2_8_30_2","volume-title":"Oral Health Surveys\u2014Basic Methods","author":"WHO","year":"2013"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124x.55840"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2010.01585.x"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01131.x"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1221"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.11.1355"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1528"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.94600"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12284"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2002.7.1.79"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/564858.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/564858.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2015\/564858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:35:04Z","timestamp":1722893704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/564858"}},"subtitle":[],"editor":[{"given":"Javier","family":"Fernandez-Solari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1155\/2015\/564858"],"URL":"https:\/\/doi.org\/10.1155\/2015\/564858","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2015-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"564858"}}