{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:17:02Z","timestamp":1782519422667,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic>This study was designed to evaluate the early results of the topical application of Hydrolyzed<jats:italic>Hibiscus esculentus<\/jats:italic>Extract 3% ointment (Myoxinol 3%), a novel local product with Botox-like activity, in the conservative treatment of chronic anal fissure (CAF).<jats:italic>Methods.<\/jats:italic>Among all patients with CAF observed during the study period, 31 subjects met the inclusion criteria and underwent medical therapy with Myoxinol 3% ointment every 12 hours for 6 weeks. Two patients were lost to follow-up. Clinical and manometric follow-up was carried out eight weeks after treatment.<jats:italic>Results.<\/jats:italic>At follow-up the success rate was 72.4% (21\/29); median VAS score and mean anal resting pressure were significantly lower if compared with respective baseline data. The only one adverse effect of the topical application of Myoxinol 3% ointment was perianal itch, which was reported by 3,4% (1\/29) of the patients available for the analysis. However, in this case this symptom did not cause interruption of the treatment.<jats:italic>Conclusions.<\/jats:italic>The topical application of Myoxinol 3% ointment in the cure of CAF shows encouraging early results. Further researches with a larger series and a longer follow-up are needed to confirm these data.<\/jats:p>","DOI":"10.1155\/2015\/567920","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T17:09:26Z","timestamp":1426525766000},"page":"1-4","source":"Crossref","is-referenced-by-count":10,"title":["Myoxinol (Hydrolyzed<i>Hibiscus esculentus<\/i>Extract) in the Cure of Chronic Anal Fissure: Early Clinical and Functional Outcomes"],"prefix":"10.1155","volume":"2015","author":[{"given":"Adolfo","family":"Renzi","sequence":"first","affiliation":[{"name":"Pelvic Care Center, \u201cVilla delle Querce\u201d Hospital, Via Battistello Caracciolo 48, 80136 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-8511","authenticated-orcid":true,"given":"Antonio","family":"Brillantino","sequence":"additional","affiliation":[{"name":"Pelvic Care Center, \u201cVilla delle Querce\u201d Hospital, Via Battistello Caracciolo 48, 80136 Naples, Italy"},{"name":"\u201cA. 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