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Fox Foundation for Parkinson\u2019s Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANM GmbH, Germany"},{"name":"Brook Henderson Group, UK"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Primary tinnitus has a severe negative influence on the quality of life of a significant portion of the general population. Acoustic coordinated reset neuromodulation is designed to induce a long-lasting reduction of tinnitus symptoms. To test acoustic coordinated reset neuromodulation as a treatment for chronic, tonal tinnitus under real life conditions, an outpatient study \u201cRESET Real Life\u201d was commissioned by ANM GmbH. Herein we present the results of this study.<jats:italic>Methods<\/jats:italic>. In a prospective, open-label, nonrandomized, noncontrolled multicenter clinical study with 200 chronic tinnitus patients, tinnitus questionnaire TBF-12 and Global Clinical Improvement-Impression Scale (CGI-I7) are used to study the safety and efficacy of acoustic coordinated reset neuromodulation. 189 patients completed the last 12-month visit, 11 patients dropped out (8 because of nontreatment related reasons; 2 because tinnitus did not change; and 1 because tinnitus got louder).<jats:italic>Results<\/jats:italic>. Acoustic coordinated reset neuromodulation caused a statistically and clinically significant decrease in TBF-12 scores as well as in CGI-I7 after 12 months of therapy under real life conditions. There were no persistent adverse events reported that were related to the therapy.<jats:italic>Conclusion<\/jats:italic>. The field study \u201cRESET Real Life\u201d provides evidence for safety and efficacy of acoustic coordinated reset neuromodulation in a prospective, open-label, real life setting.<\/jats:p>","DOI":"10.1155\/2015\/569052","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T11:46:36Z","timestamp":1445341596000},"page":"1-8","source":"Crossref","is-referenced-by-count":21,"title":["Acoustic Coordinated Reset Neuromodulation in a Real Life Patient Population with Chronic Tonal Tinnitus"],"prefix":"10.1155","volume":"2015","author":[{"given":"Christian","family":"Hauptmann","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Medicine-Neuromodulation (INM-7), J\u00fclich Research Center, 52425 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Str\u00f6bel","sequence":"additional","affiliation":[{"name":"CERES GmbH Evaluation & Research, 79539 L\u00f6rrach, 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