{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:07:52Z","timestamp":1763726872546,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":3423,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    This case report describes the changes in caries risk and activity and dental treatment of a 9\u2010year\u2010old patient who presented with signs and symptoms of Niemann\u2010Pick disease type C (NPC).\n                    <jats:italic>Treatment.<\/jats:italic>\n                    The preventive dental treatment included instructions to caregivers for oral hygiene and diet. A calcium hydroxide pulpotomy and restorative dental treatments were performed in a dental office with desensitization techniques and behavioral management. The patient was attended every 3 months for the control of dental plaque biofilm, for topical fluoride application, and for observing the pulpotomized tooth.\n                    <jats:italic>Results.<\/jats:italic>\n                    The bacterial plaque biofilm was being adequately controlled by the caregiver. After 2 years, the clinical and radiographic examination of the pulpotomized tooth showed the absence of internal root resorption and bone rarefaction, and clinical examination showed tooth sensitivity, dental pain, and gingival swelling.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    The pulpotomy prevented clinical and radiographic success. Dentists must be aware of and be able to identify systemic and local aspects associated with caries risk of children with NPC disease. Furthermore, dentists must employ stringent preventive measures and provide instructions to caregivers to reduce caries risk.\n                  <\/jats:p>","DOI":"10.1155\/2015\/571098","type":"journal-article","created":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T16:02:49Z","timestamp":1420128169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in Caries Risk and Activity of a 9\u2010Year\u2010Old Patient with Niemann\u2010Pick Disease Type C"],"prefix":"10.1155","volume":"2015","author":[{"given":"K\u00e9ssia Su\u00eania Fidelis","family":"Mesquita-Guimar\u00e3es","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andiara","family":"De Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldevina Campos","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Nelson-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Assed","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra Mussolino","family":"de Queiroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_1_2","DOI":"10.1016\/b978-0-444-59565-2.00041-1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_2_2","DOI":"10.1016\/j.mcn.2009.07.013"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_2","DOI":"10.1034\/j.1399-0004.2003.00147.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_2","DOI":"10.1186\/1750-1172-5-16"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_2","DOI":"10.1086\/320599"},{"volume-title":"GeneReviews [Internet]","year":"2000","author":"Patterson M.","key":"e_1_2_8_6_2"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_2","DOI":"10.1212\/01.wnl.0000345040.01917.9d"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_2","DOI":"10.1016\/j.ymgme.2009.06.008"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_2","DOI":"10.1016\/j.bbalip.2004.08.009"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_2","DOI":"10.1111\/j.1600-0528.1997.tb00894.x"},{"key":"e_1_2_8_11_2","first-page":"179","article-title":"Guideline on caries-risk assessment and management for infants, children, and adolescents","volume":"31","author":"American Academy of Pediatric Dentistry","year":"2011","journal-title":"Pediatric Dentistry"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_2","DOI":"10.1111\/j.1754-4505.2009.00122.x"},{"key":"e_1_2_8_13_2","first-page":"125","article-title":"Guideline on behavior guidance for the pediatric dental patient","volume":"30","author":"American Academy of Pediatric Dentistry","year":"2011","journal-title":"Journal of Pediatric Dentistry"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_2","DOI":"10.1007\/bf03262738"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_2","DOI":"10.1016\/j.tripleo.2007.06.005"},{"key":"e_1_2_8_16_2","first-page":"107","article-title":"Guideline on management of dental patients with special health care needs","volume":"30","author":"American Academy of Pediatric Dentistry","year":"2011","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_8_17_2","first-page":"213","article-title":"The healing of wounds of the dental pulp of man. 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