{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:26:17Z","timestamp":1792081577939,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To compare the penetration of riboflavin using a microscope-integrated real time spectral domain optical coherence tomography (ZEISS OPMI LUMERA 700 and ZEISS RESCAN 700) in keratoconus patients undergoing accelerated collagen crosslinking (ACXL) between epithelium on (epi-on) and epithelium off (epi-off).<jats:italic>Methods<\/jats:italic>. Intraoperative images were obtained during each of the procedures. Seven keratoconus patients underwent epi-on ACXL and four underwent epi-off ACXL. A software tool was developed using Microsoft.NET and Open Computer Vision (OpenCV) libraries for image analysis. Pre- and postprocedure images were analyzed for changes in the corneal hyperreflectance pattern as a measure of the depth of riboflavin penetration.<jats:italic>Results<\/jats:italic>. The mean corneal hyperreflectance in the epi-on group was 12.97 \u00b1 1.49 gray scale units (GSU) before instillation of riboflavin and 14.46 \u00b1 2.09\u2009GSU after AXCL (<jats:italic>P<\/jats:italic>= 0.019) while in the epi-off group it was 11.43 \u00b1 2.68\u2009GSU and 16.98 \u00b1 8.49\u2009GSU, respectively (<jats:italic>P<\/jats:italic>= 0.002). The average depth of the band of hyperreflectance in the epi-on group was 149.39 \u00b1 15.63 microns and in the epi-off group it was 191.04 \u00b1 32.18 microns.<jats:italic>Conclusion<\/jats:italic>. This novel<jats:italic>in vivo<\/jats:italic>, real time imaging study demonstrates riboflavin penetration during epi-on and epi-off ACXL.<\/jats:p>","DOI":"10.1155\/2015\/572698","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T11:08:44Z","timestamp":1428491324000},"page":"1-7","source":"Crossref","is-referenced-by-count":15,"title":["Intraoperative Optical Coherence Tomography Using the RESCAN 700: Preliminary Results in Collagen Crosslinking"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-2110","authenticated-orcid":true,"given":"Natasha","family":"Pahuja","sequence":"first","affiliation":[{"name":"Department of Cornea & Refractive Surgery, Narayana Nethralaya 121\/C, Chord Road, 1st \u201cR\u201d Block, Rajajinagar, Bangalore, Karnataka 560 010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Cornea & Refractive Surgery, Narayana Nethralaya 121\/C, Chord Road, 1st \u201cR\u201d Block, Rajajinagar, Bangalore, Karnataka 560 010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8392-7159","authenticated-orcid":true,"given":"Chaitra","family":"Jayadev","sequence":"additional","affiliation":[{"name":"Department of Cornea & Refractive Surgery, Narayana Nethralaya 121\/C, Chord Road, 1st \u201cR\u201d Block, Rajajinagar, Bangalore, Karnataka 560 010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-9660","authenticated-orcid":true,"given":"Rudy","family":"Nuijts","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maastricht University Medical Center, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath","family":"Hedge","sequence":"additional","affiliation":[{"name":"Forus Health Pvt. 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