{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:28:52Z","timestamp":1740169732338,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consent to undergo Na18<\/jats:sup>F\u2212<\/jats:sup>PET\/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curve eliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions were compared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal) bone, and muscle. TheSUV<\/mml:mtext><\/mml:mrow>m<\/mml:mi><\/mml:mrow><\/mml:msub>(<\/mml:mo>t<\/mml:mi>)<\/mml:mo><\/mml:math>(m<\/mml:mi>=<\/mml:mo>m<\/mml:mtext>a<\/mml:mtext>x<\/mml:mtext><\/mml:math>, mean) and a series of slopes were computed as(<\/mml:mo>SUV<\/mml:mtext><\/mml:mrow>m<\/mml:mi><\/mml:mrow><\/mml:msub>(<\/mml:mo>t<\/mml:mi><\/mml:mrow>i<\/mml:mi><\/mml:mrow><\/mml:msub>)<\/mml:mo>-<\/mml:mo>SUV<\/mml:mtext><\/mml:mrow>m<\/mml:mi><\/mml:mrow><\/mml:msub>(<\/mml:mo>t<\/mml:mi><\/mml:mrow>j<\/mml:mi><\/mml:mrow><\/mml:msub>)<\/mml:mo>)<\/mml:mo>\/<\/mml:mo>(<\/mml:mo>t<\/mml:mi><\/mml:mrow>i<\/mml:mi><\/mml:mrow><\/mml:msub>-<\/mml:mo>t<\/mml:mi><\/mml:mrow>j<\/mml:mi><\/mml:mrow><\/mml:msub>)<\/mml:mo><\/mml:math>, for pairs of time valuest<\/mml:mi><\/mml:mrow>i<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>andt<\/mml:mi><\/mml:mrow>j<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>. A Patlak-like analysis was performed for the same time values by computing(<\/mml:mo>(<\/mml:mo>VOI<\/mml:mtext><\/mml:mrow>p<\/mml:mi><\/mml:mrow><\/mml:msub>(<\/mml:mo>t<\/mml:mi><\/mml:mrow>i<\/mml:mi><\/mml:mrow><\/mml:msub>)<\/mml:mo>\/<\/mml:mo>VOI<\/mml:mtext><\/mml:mrow>e<\/mml:mi><\/mml:mrow><\/mml:msub>(<\/mml:mo>t<\/mml:mi><\/mml:mrow>i<\/mml:mi><\/mml:mrow><\/mml:msub>)<\/mml:mo>)<\/mml:mo>-<\/mml:mo>(<\/mml:mo>VOI<\/mml:mtext><\/mml:mrow>p<\/mml:mi><\/mml:mrow><\/mml:msub>(<\/mml:mo>t<\/mml:mi><\/mml:mrow>j<\/mml:mi><\/mml:mrow><\/mml:msub>)<\/mml:mo>\/<\/mml:mo>VOI<\/mml:mtext><\/mml:mrow>e<\/mml:mi><\/mml:mrow><\/mml:msub>(<\/mml:mo>t<\/mml:mi><\/mml:mrow>j<\/mml:mi><\/mml:mrow><\/mml:msub>)<\/mml:mo>)<\/mml:mo>)<\/mml:mo>\/<\/mml:mo>(<\/mml:mo>t<\/mml:mi><\/mml:mrow>i<\/mml:mi><\/mml:mrow><\/mml:msub>-<\/mml:mo>t<\/mml:mi><\/mml:mrow>j<\/mml:mi><\/mml:mrow><\/mml:msub>)<\/mml:mo><\/mml:math>, wherep<\/jats:italic>= broken bone, other bone, and muscle ande<\/jats:italic>= expected activity in a VOI. Paired comparisons between Patlak-like andSUV<\/mml:mtext><\/mml:mrow>m<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>slopes showed good agreement by both linear regression and correlation coefficient analysis (r<\/mml:mi>=<\/mml:mo>84<\/mml:mn>%<\/mml:mi>,<\/mml:mo>r<\/mml:mi><\/mml:mrow>s<\/mml:mi><\/mml:mrow><\/mml:msub>=<\/mml:mo>78<\/mml:mn>%<\/mml:mi>-<\/mml:mtext>SUV<\/mml:mtext><\/mml:mrow>max<\/mml:mtext><\/mml:mrow><\/mml:msub>,<\/mml:mo>r<\/mml:mi>=<\/mml:mo>92<\/mml:mn>%<\/mml:mi><\/mml:math>, andr<\/mml:mi><\/mml:mrow>s<\/mml:mi><\/mml:mrow><\/mml:msub>=<\/mml:mo>91<\/mml:mn>%<\/mml:mi>-<\/mml:mtext>SUV<\/mml:mtext><\/mml:mrow>mean<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:math>), suggesting static scans could substitute for dynamic studies. Patlak-like slope differences of 0.1\u2009min\u22121<\/jats:sup>or greater between examinations andSU<\/mml:mtext>V<\/mml:mtext><\/mml:mrow>max<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:math>differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of \u22120.06\u2009min\u22121<\/jats:sup>usually indicated poor remodeling progress in this cohort.<\/jats:p>","DOI":"10.1155\/2015\/574705","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T17:02:58Z","timestamp":1441645378000},"page":"1-11","source":"Crossref","is-referenced-by-count":3,"title":["Using PET\/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences"],"prefix":"10.1155","volume":"2015","author":[{"given":"Henrik","family":"Lundblad","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald Q.","family":"Maguire","sequence":"additional","affiliation":[{"name":"School of Information and Communication Technology, KTH Royal Institute of Technology, 16440 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Karlsson-Thur","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5870-2975","authenticated-orcid":true,"given":"Cathrine","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Department of Hospital Physics, Karolinska University Hospital Solna, 17176 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn E.","family":"Noz","sequence":"additional","affiliation":[{"name":"Department of Radiology, New York 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