{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:11:31Z","timestamp":1773270691742,"version":"3.50.1"},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Chresta martii<\/jats:italic>(Asteraceae) is a species widely used by the population of the Xingu region of Sergipe, Brazil, in the form of a decoction (aerial parts) for the treatment of gastrointestinal diseases. The study aims to assess the gastroprotective activity of organic extracts and semipurified fractions and identify the principal compounds present in<jats:italic>C. martii<\/jats:italic>responsible for such activity. The organic extracts (cyclohexane: ECCm, ethyl acetate: EACm, and ethanol: EECm) were obtained from the dried aerial parts (500\u2009g) of<jats:italic>C. martii<\/jats:italic>. For evaluation of the gastroprotective activity of extracts (50, 100, or 200\u2009mg\/kg; p.o.), male<jats:italic>Swiss Webster<\/jats:italic>mice (25\u201330\u2009g) were used which had gastric ulcers induced by indomethacin (40\u2009mg\/kg, s.c.) or ethanol (0.2\u2009mL\/animal; p.o.). Among the extracts evaluated, EACm exhibited significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) gastroprotective activity in the models used. The fractionation of EACm was performed in a silica gel column 60 eluted with the following compounds: [chloroform\u2014F1 yield (10%)], [chloroform\/ethyl acetate (1\/1)\u2014F2 yield (6%)], [ethyl acetate\u2014F3 yield (8%)], and [ethyl\/methanol acetate (1\/1)\u2014F4 yield (5%)]. Of the fractions described above, the F1 (25\u2009mg\/kg; p.o.) had greater gastroprotective activity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) than that displayed by ranitidine (80\u2009mg\/kg; p.o.) in the ethanol-induced ulcer model. The refractionation of F1 produced 23 subfractions and from these two yellow amorphous compounds were obtained by recrystallization, Rf: 0.46 and 0.31 (ethyl acetate\u2009:\u2009chloroform 5\u2009:\u20095). The compounds isolated were characterized by nuclear magnetic resonance spectroscopy (<jats:sup>1<\/jats:sup>H-NMR and<jats:sup>13<\/jats:sup>C-NMR) and identified as flavones: chrysoeriol (yield: 0.43%) and 3\u2032,4\u2032-dimethoxyluteolin (yield: 0.58%).<jats:italic>Conclusion<\/jats:italic>. Flavone 3\u2032,4\u2032-dimethoxyluteolin is the principal compound present in the species<jats:italic>C. martii<\/jats:italic>and is probably responsible for gastroprotective activity observed in this species.<\/jats:p>","DOI":"10.1155\/2015\/576495","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T18:39:56Z","timestamp":1426617596000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Study of the Gastroprotective Effect of Extracts and Semipurified Fractions of<i>Chresta martii<\/i>DC. and Identification of Its Principal Compounds"],"prefix":"10.1155","volume":"2015","author":[{"given":"E. S.","family":"Franco","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Laboratory of Pharmacology of Bioactive Products, Federal University of Pernambuco (UFPE), Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E. B.","family":"M\u00e9lo","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Laboratory of Mutagenesis and Research Center Aggeu Magalh\u00e3es, Fiocruz Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J. A.","family":"Jatob\u00e1","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Laboratory of Pharmacology of Bioactive Products, Federal University of Pernambuco (UFPE), Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L. B. D.","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Antibiotics, Laboratory of Chemistry of Natural Products, UFPE, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A. R.","family":"Silva","sequence":"additional","affiliation":[{"name":"Sobral Laboratory of Pharmacology, Federal University of Cear\u00e1 (UFC), CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. G.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Antibiotics, Laboratory of Bioassays for Research on Drugs, UFPE, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Antibiotics, Laboratory of Chemistry of Natural Products, UFPE, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B. 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