{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:36:53Z","timestamp":1760985413247,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81071145"],"award-info":[{"award-number":["81071145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Manganese-enhanced MRI (MEMRI) has been applied to a wide range of biological and disease research. The purpose of the study was to use MEMRI to diagnose the acute mesenteric ischemia (AMI).<jats:italic>Methods<\/jats:italic>. The institutional experimental animal ethics committee approved this study. To optimize the dose of Mn<jats:sup>2+<\/jats:sup>infusion, a dose-dependent curve was obtained using Mn<jats:sup>2+<\/jats:sup>-enhanced<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>map MRI by an intravenous infusion 2.5\u201320\u2009nmol\/g body weight (BW) of 50\u2009nmol\/L MnCl<jats:sub>2<\/jats:sub>. The eighteen animals were divided into control, sham-operated, and AMI groups. AMI models were performed by ligating the superior mesenteric artery (SMA).<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>values were measured on<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>maps in regions of the small intestinal wall and relaxation rate (\u0394<jats:italic>R<\/jats:italic><jats:sub>1<\/jats:sub>) was calculated.<jats:italic>Results<\/jats:italic>. A nonlinear relationship between infused MnCl<jats:sub>2<\/jats:sub>solution dose and increase in small intestinal wall \u0394<jats:italic>R<\/jats:italic><jats:sub>1<\/jats:sub>was observed. Control animal exhibited significant Mn<jats:sup>2+<\/jats:sup>clearance over time at the dose of 15\u2009nmol\/g BW. In the AMI model, \u0394<jats:italic>R<\/jats:italic><jats:sub>1<\/jats:sub>values (0.95 \u00b1 0.13) in the small intestinal wall were significantly lower than in control group (2.05 \u00b1 0.19) after Mn<jats:sup>2+<\/jats:sup>infusion (<jats:italic>P<\/jats:italic>&lt; 0.01).<jats:italic>Conclusion<\/jats:italic>. The data suggest that MEMRI shows potential as a diagnostic technique that is directly sensitive to the poor or absent perfusion in AMI.<\/jats:p>","DOI":"10.1155\/2015\/579639","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T16:01:31Z","timestamp":1448553691000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["A New Approach Using Manganese-Enhanced MRI to Diagnose Acute Mesenteric Ischemia in a Rabbit Model: Initial Experience"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-4719","authenticated-orcid":true,"given":"Da-wei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute 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