{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:18:31Z","timestamp":1790255911390,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"French Ministry of Health","award":["PHRC-N 2008-1004"],"award-info":[{"award-number":["PHRC-N 2008-1004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    The objective of this study was to compare glucose metabolism and atrophy, in the precuneus and cingulate cortex, in patients with Alzheimer\u2019s disease (AD) and mild cognitive impairment (MCI), using FreeSurfer.\n                    <jats:italic>Methods.<\/jats:italic>\n                    47 individuals (17 patients with AD, 17 patients with amnestic MCI, and 13 healthy controls (HC)) were included. MRI and PET images using\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG (mean injected dose of 185\u2009MBq) were acquired and analyzed using FreeSurfer to define regions of interest in the hippocampus, amygdala, precuneus, and anterior and posterior cingulate cortex. Regional volumes were generated. PET images were registered to the T1-weighted MRI images and regional uptake normalized by cerebellum uptake (SUVr) was measured.\n                    <jats:italic>Results.<\/jats:italic>\n                    Mean posterior cingulate volume was reduced in MCI and AD. SUVr were different between the three groups: mean precuneus SUVr was 1.02 for AD, 1.09 for MCI, and 1.26 for controls (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ); mean posterior cingulate SUVr was 0.96, 1.06, and 1.22 for AD, MCI, and controls, respectively (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    We found graduated hypometabolism in the posterior cingulate cortex and the precuneus in prodromal AD (MCI) and AD, whereas atrophy was not significant. This suggests that the use of\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG in these two regions could be a neurodegenerative biomarker.\n                  <\/jats:p>","DOI":"10.1155\/2015\/583931","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T04:34:56Z","timestamp":1433392496000},"page":"1-8","source":"Crossref","is-referenced-by-count":123,"title":["Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer\u2019s Disease and Mild Cognitive Impairment: MRI and\n                    <sup>18<\/sup>\n                    F-FDG PET Quantitative Analysis Using FreeSurfer"],"prefix":"10.1155","volume":"2015","author":[{"given":"Matthieu","family":"Bailly","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, CHRU de Tours, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"Service de M\u00e9decine Nucl\u00e9aire, CHR Orl\u00e9ans, avenue de l\u2019H\u00f4pital, 45000 Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Destrieux","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hommet","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"Consultation M\u00e9moire, CHRU de Tours, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Mondon","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"Consultation M\u00e9moire, CHRU de Tours, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Cottier","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"Service de Neuroradiologie, CHRU de Tours, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Beaufils","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"Consultation M\u00e9moire, CHRU de Tours, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Vierron","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"INSERM CIC 1415, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Vercouillie","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9ziane","family":"Ibazizene","sequence":"additional","affiliation":[{"name":"CEA\/DSV\/I2BM\/CI-NAPS UMR6232, 14000 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Voisin","sequence":"additional","affiliation":[{"name":"INSERM U825, Universit\u00e9 Paul Sabatier, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Payoux","sequence":"additional","affiliation":[{"name":"INSERM U825, Universit\u00e9 Paul Sabatier, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Barr\u00e9","sequence":"additional","affiliation":[{"name":"CEA\/DSV\/I2BM\/CI-NAPS UMR6232, 14000 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Camus","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"Consultation M\u00e9moire, CHRU de Tours, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Guilloteau","sequence":"additional","affiliation":[{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"INSERM CIC 1415, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Joao","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, CHRU de Tours, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"INSERM U930, Universit\u00e9 Fran\u00e7ois Rabelais, boulevard Tonnell\u00e9, 37000 Tours, France"},{"name":"INSERM CIC 1415, boulevard Tonnell\u00e9, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(07)70178-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(14)70090-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(10)70223-4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/bf00308809"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.967"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/2011272193"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1397"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp123"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073377"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-014-9233-6"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2177-05.2005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.34.7.939"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2011-0028"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.07.008"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.01.022"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2010-100201"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1159\/000320136"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.78"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-012-0246-x"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050110029003"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420114"},{"key":"26","year":"2011"},{"issue":"1","key":"27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","year":"1995","journal-title":"Journal of the Royal Statistical Society. Series B. Methodological"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021896"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.115006"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3182839fbc"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-4580(01)00230-5"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm288"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091402"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.02.010"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1762-7"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(02)00569-x"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.037"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038234"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199507000-00006"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.017"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.11.026"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.05.013"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.025"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.03.017"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4228"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.2008"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/583931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/583931.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/583931.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T06:14:15Z","timestamp":1717913655000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/583931\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":47,"alternative-id":["583931","583931"],"URL":"https:\/\/doi.org\/10.1155\/2015\/583931","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}