{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:16:27Z","timestamp":1783937787596,"version":"3.55.0"},"reference-count":54,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>We evaluated results of temozolomide (TMZ) therapy in six patients, aged 34\u201378 years, presenting aggressive pituitary tumors. In all the patients tested O<jats:sup>6<\/jats:sup>-methylguanine-DNA methyltransferase (MGMT) immunoexpression in surgical specimens was absent. Patients received temozolomide 140\u2013320\u2009mg\/day for 5 days monthly for at least 3 months. In two patients minimum time for evaluation could not be reached because of death in a 76-year-old man with a malignant prolactinoma and of severe neutro-thrombopenia in a 47-year-old woman with nonfunctioning pituitary adenoma. In two patients (a 34-year-old acromegalic woman and a 39-year-old woman with Nelson\u2019s syndrome) no response was observed after 4 and 6 months, respectively, and the treatment was stopped. Conversely, two 52- and 42-year-old women with Cushing\u2019s disease had long-term total clinical and radiological remissions which persisted after stopping temozolomide. We conclude that TMZ therapy may be of variable efficacy depending on\u2014until now\u2014incompletely understood factors. Cooperative work on a greater number of cases of aggressive pituitary tumors should be crucial to establish the indications, doses, and duration of temozolomide administration.<\/jats:p>","DOI":"10.1155\/2015\/587893","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T11:33:41Z","timestamp":1432812821000},"page":"1-8","source":"Crossref","is-referenced-by-count":44,"title":["Temozolomide Therapy for Aggressive Pituitary Tumors: Results in a Small Series of Patients from Argentina"],"prefix":"10.1155","volume":"2015","author":[{"given":"Oscar D.","family":"Bruno","sequence":"first","affiliation":[{"name":"Foundation of Endocrinology, 1425 Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Ju\u00e1rez-Allen","sequence":"additional","affiliation":[{"name":"Foundation of Endocrinology, 1425 Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia 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