{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:15:32Z","timestamp":1753881332389,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Haemophilia A is a congenital disorder of coagulation that mainly affects males and causes a considerable use of resources, especially when hemophilic patients are treated with prophylaxis. The aim of the present review was to discuss and appraise the methodological aspects and results of published economic evaluations of haemophilia A treatments in the last decade. <jats:italic>Methods<\/jats:italic>. The literature search, performed by consulting four engines, covered studies published between 2002 and 2014. Full economic evaluations published in English language were identified and included in the review. A quality assessment of the studies was also carried out based on Drummond\u2019s checklist. <jats:italic>Results<\/jats:italic>. After careful evaluations of the identified records, 5 studies were reviewed. Primary and secondary prophylaxis resulted cost\u2010effective compared to on\u2010demand therapy: the ICER of primary prophylaxis ranged from \u20ac40.236 to \u20ac59.315\/QALY gained, while the ICER of secondary prophylaxis was \u20ac40.229\/QALY gained. Furthermore, 60% were high quality and 40% were medium quality studies. <jats:italic>Conclusions<\/jats:italic>. The review underlines the cost\u2010effectiveness of prophylaxis versus on\u2010demand treatment and the different methodological approaches applied. Further economic evaluations are required with models that reflect the clinical reality and consumption of resources in each country.<\/jats:p>","DOI":"10.1155\/2015\/596164","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T21:44:46Z","timestamp":1420494286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Haemophilia A: Pharmacoeconomic Review of Prophylaxis Treatment versus On\u2010Demand"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-9098","authenticated-orcid":false,"given":"Brigid","family":"Unim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Assunta","family":"Veneziano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Boccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"La Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,5]]},"reference":[{"key":"e_1_2_7_1_2","unstructured":"AbbonizioF. 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