{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:37:13Z","timestamp":1767983833790,"version":"3.49.0"},"reference-count":6,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Factor V deficiency secondary to inhibitors is extremely rare and can be caused by a wide collection of exposures such as bovine thrombin and beta lactamase antibiotics. The management of factor V deficiency with inhibitor is a condition treated based on case reports due to the rarity of this condition. We describe a complicated case of an elderly patient with severe factor V deficiency with high inhibitor titer refractory to FEIBA (anti-inhibitor coagulation complex) treated with NovoSeven concurrently with cyclosporine immunosuppression and Rituxan. Given that there are no consensus guidelines on treatment, this case offers important insight into the therapeutic approaches that can be used to treat such patients.<\/jats:p>","DOI":"10.1155\/2015\/603402","type":"journal-article","created":{"date-parts":[[2015,8,9]],"date-time":"2015-08-09T21:03:46Z","timestamp":1439154226000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor"],"prefix":"10.1155","volume":"2015","author":[{"given":"Elizabeth S.","family":"John","sequence":"first","affiliation":[{"name":"Department of Medicine, Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08901, USA"},{"name":"University of Central Florida, 4000 Central Florida Boulevard, Orlando, FL 32816, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minesh D.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of Florida Health Cancer Center in Orlando, 1400 S Orange Avenue, MP700, Orlando, FL 32806, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Hajdenberg","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of Florida Health Cancer Center in Orlando, 1400 S Orange Avenue, MP700, Orlando, FL 32806, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","first-page":"79","volume-title":"Acquired coagulation disorders caused by inhibitors","year":"2013"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412Y.0000000072"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-010-0529-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-162453"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1160\/th05-04-0279"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1160\/th08-11-0767"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2015\/603402.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2015\/603402.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2015\/603402.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T22:56:21Z","timestamp":1469660181000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crihem\/2015\/603402\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":6,"alternative-id":["603402","603402"],"URL":"https:\/\/doi.org\/10.1155\/2015\/603402","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}