{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:03:30Z","timestamp":1793934210298,"version":"4.8.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. ST2, a member of the interleukin\u20101 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. IL\u201033 is a specific ligand of ST2. The aim of the study was to determine whether serum levels of soluble ST2 (sST2) or IL\u201033 predict activity of the disease in patients with ANCA\u2010associated vasculitides (AAV). <jats:italic>Methods<\/jats:italic>. 139 AAV patients and 62 controls were studied. IL\u201033 and sST2 in the blood were measured with a commercially available ELISA. <jats:italic>Results<\/jats:italic>. Newly diagnosed AAV patients had higher sST2 levels than controls (<jats:italic>P<\/jats:italic> &lt; 0.01). Levels of sST2 were significantly higher in active newly diagnosed AAV patients than in patients with remission (<jats:italic>P<\/jats:italic> &lt; 0.001). IL\u201033 levels were higher in AAV patients than in the control groups (<jats:italic>P<\/jats:italic> = 0.002). However, serum IL\u201033 levels were not increased in patients with active AAV compared to patients in remission. IL\u201033 levels were higher in patients with granulomatosis with polyangiitis than in patients with microscopic polyangiitis (<jats:italic>P<\/jats:italic> = 0.012). <jats:italic>Conclusions<\/jats:italic>. Serum sST2, but not serum IL\u201033, may be a marker of activity in AAV patients.<\/jats:p>","DOI":"10.1155\/2015\/603750","type":"journal-article","created":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T23:12:57Z","timestamp":1424733177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Increased Levels of Soluble ST2 in Patients with Active Newly Diagnosed ANCA\u2010Associated Vasculitis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Z.","family":"Hladinova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Hruskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Svobodova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Malickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Lanska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Konop\u00e1sek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Jancova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rysava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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