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Upon differentiation, the generated GM\u2010 or M\u2010BMMs were characterized by morphological analyses, gene expression profiles, and cytokines production. Our main results demonstrate that GM\u2010BMMs derived from A\/J and B.10 produced high levels of pro\u2010 and anti\u2010inflammatory cytokines that may contribute to generate an unbalanced early immune response. In accordance with the literature, the B10.A susceptible mice lineage has an innate tendency to polarize into M1\u2010like phenotype, whereas the opposite phenotype occurs in A\/J resistance mice. In this context, our data support that susceptibility and resistance are strongly correlated with M1 and M2 polarization, respectively.<\/jats:p>","DOI":"10.1155\/2015\/605450","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T20:44:48Z","timestamp":1444769088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Effects of <i>Paracoccidioides brasiliensis<\/i> Infection on GM\u2010CSF\u2010 and M\u2010CSF\u2010Induced Mouse Bone Marrow\u2010Derived Macrophage from Resistant and Susceptible Mice Strains"],"prefix":"10.1155","volume":"2015","author":[{"given":"Calliandra","family":"de Souza Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo Henrique","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio","family":"Sousa Jeronimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Soares de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"da Silveira Derengowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anam\u00e9lia","family":"Lorenzetti Bocca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildinete","family":"Silva-Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,12]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"S16","article-title":"Microbiology of systemic fungal infections","volume":"51","author":"Chakrabarti A.","year":"2005","journal-title":"Journal of Postgraduate Medicine"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12098"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080325"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.922"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.42.3.1367-1369.2004"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1405.071312"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.06.017"},{"key":"e_1_2_9_8_2","first-page":"187","article-title":"Intestinal perforation with invasive candidiasis in an immunocompetent adult","volume":"14","author":"Thorpe J.","year":"2004","journal-title":"Journal of the College of Physicians and Surgeons\u2014Pakistan"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0074-02762009000300019"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12472"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-007-9048-1"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.12703\/p6-81"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x1998000500003"},{"key":"e_1_2_9_14_2","first-page":"585","article-title":"Susceptibility and resistance of inbred mice to Paracoccidioides brasiliensis","volume":"66","author":"Garcia Calich V. 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