{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:14:56Z","timestamp":1789996496401,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To provide a comprehensive appraisal of the evidence from secondary research on cardiac regenerative therapy.<jats:italic>Study Design and Setting<\/jats:italic>. Overview of systematic reviews of controlled clinical trials concerning stem cell administration or mobilization in patients with cardiovascular disease.<jats:italic>Results<\/jats:italic>. After a systematic database search, we short-listed 41 reviews (660 patients). Twenty-two (54%) reviews focused on acute myocardial infarction (AMI), 19 (46%) on chronic ischemic heart disease (IHD) or heart failure (HF), 29 (71%) on bone marrow-derived stem-cells (BMSC), and 36 (88%) to randomized trials only. Substantial variability among reviews was found for validity (AMSTAR score: median 9 [minimum 3]; 1st quartile 9; 3rd quartile 10; maximum 11), effect estimates (change in ejection fraction from baseline to follow-up: 3.47% [0.02%; 2.90%; 4.22%; 6.11%]), and citations (Web of Science yearly citations: 4.1 [0; 2.2; 6.5; 68.9]). No significant association was found between these three features. However, reviews focusing on BMSC therapy had higher validity scores (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.008<\/mml:mn><\/mml:math>) and showed more pronounced effect estimates (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.002<\/mml:mn><\/mml:math>). Higher citations were associated with journal impact factor (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.007<\/mml:mn><\/mml:math>), corresponding author from North America\/Europe (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.022<\/mml:mn><\/mml:math>), and inclusion of nonrandomized trials (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.046<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Substantial heterogeneity is apparent among these reviews in terms of quality and effect estimates.<\/jats:p>","DOI":"10.1155\/2015\/613782","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T17:03:30Z","timestamp":1434387810000},"page":"1-7","source":"Crossref","is-referenced-by-count":28,"title":["State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-8495","authenticated-orcid":true,"given":"Mariangela","family":"Peruzzi","sequence":"first","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"De Falco","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Abbate","sequence":"additional","affiliation":[{"name":"VCU Pauley Heart Center, Virginia Commonwealth University, 821 West Franklin Street, Richmond, VA 23284, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Biondi-Zoccai","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy"},{"name":"VCU Pauley Heart Center, Virginia Commonwealth University, 821 West Franklin Street, Richmond, VA 23284, USA"},{"name":"Fondazione Eleonora Lorillard Spencer Cenci, 00185 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0865-8814","authenticated-orcid":true,"given":"Isotta","family":"Chimenti","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Lotrionte","sequence":"additional","affiliation":[{"name":"Heart Failure and Cardiac Rehabilitation Unit, Columbus Integrated Complex, Via Giuseppe Moscati 31, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Oxford Heart Center, Oxford University Hospital, Headley Way, Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Delewi","sequence":"additional","affiliation":[{"name":"Academic Medical Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino G. 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