{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:22:43Z","timestamp":1771474963194,"version":"3.50.1"},"reference-count":79,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306258\/2011-0"],"award-info":[{"award-number":["306258\/2011-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2011\/19467-0"],"award-info":[{"award-number":["2011\/19467-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2010\/20756-4"],"award-info":[{"award-number":["2010\/20756-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"S\u00e3o Paulo State Research Foundation","award":["306258\/2011-0"],"award-info":[{"award-number":["306258\/2011-0"]}]},{"name":"S\u00e3o Paulo State Research Foundation","award":["2011\/19467-0"],"award-info":[{"award-number":["2011\/19467-0"]}]},{"name":"S\u00e3o Paulo State Research Foundation","award":["2010\/20756-4"],"award-info":[{"award-number":["2010\/20756-4"]}]},{"name":"S\u00e3o Paulo State Research Foundation","award":["306258\/2011-0"],"award-info":[{"award-number":["306258\/2011-0"]}]},{"name":"S\u00e3o Paulo State Research Foundation","award":["2011\/19467-0"],"award-info":[{"award-number":["2011\/19467-0"]}]},{"name":"S\u00e3o Paulo State Research Foundation","award":["2010\/20756-4"],"award-info":[{"award-number":["2010\/20756-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>This study investigated the antioxidant system response of male reproductive organs during early and late phases of diabetes and the influence of melatonin treatment. Melatonin was administered to five-week-old Wistar rats throughout the experiment, in drinking water (10\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg b.w). Diabetes was induced at 13 weeks of age by streptozotocin (4.5\u2009mg\/100\u2009g b.w., i.p.) and animals were euthanized with 14 or 21 weeks old. Activities of catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), and lipid peroxidation were evaluated in prostate, testis, and epididymis. The enzymes activities and lipid peroxidation were not affected in testis and epididymis after one or eight weeks of diabetes. Prostate exhibited a 3-fold increase in GPx activity at short-term diabetes and at long-term diabetes there were 2- and 3-fold increase in CAT and GST, respectively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). Melatonin treatment to healthy rats caused a 47% increase in epididymal GPx activity in 14-week-old rats. In prostate, melatonin administration normalized GST activity at both ages and mitigated GPx at short-term and CAT at long-term diabetes. The testis and epididymis were less affected by diabetes than prostate. Furthermore, melatonin normalized the enzymatic disorders in prostate demonstrating its effective antioxidant role, even at low dosages.<\/jats:p>","DOI":"10.1155\/2015\/614579","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T21:02:36Z","timestamp":1430946156000},"page":"1-11","source":"Crossref","is-referenced-by-count":26,"title":["Effect of Melatonin Intake on Oxidative Stress Biomarkers in Male Reproductive Organs of Rats under Experimental Diabetes"],"prefix":"10.1155","volume":"2015","author":[{"given":"Marina G.","family":"Gobbo","sequence":"first","affiliation":[{"name":"Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, Universidade Estadual Paulista (UNESP), Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"},{"name":"Department of Cell Biology, Institute of Biology, State University of Campinas (UNICAMP), Charles Darwin Street, Building N, 13083 863 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina F. Pereira","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, Universidade Estadual Paulista (UNESP), Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"},{"name":"Department of Cell Biology, Institute of Biology, State University of Campinas (UNICAMP), Charles Darwin Street, Building N, 13083 863 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo G. Humberto","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, Universidade Estadual Paulista (UNESP), Crist\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"},{"name":"Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, Universidade Estadual Paulista (UNESP), Cris\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo A.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, Universidade Estadual Paulista (UNESP), Cris\u00f3v\u00e3o Colombo 2265, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rejane M.","family":"G\u00f3es","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Institute of Biology, State University of Campinas (UNICAMP), Charles Darwin Street, Building N, 13083 863 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","year":"2014"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1152\/ajpendo.2001.280.5.E685","volume":"280","year":"2001","journal-title":"The American Journal of Physiology\u2014Endocrinology and Metabolism"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079x.1998.tb00545.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-010-0607-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2531"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(99)00079-9"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m310145200"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.87"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051578"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2337\/diab.23.4.306"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2190"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1815-8"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1530\/JME-13-0152"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24044"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25360"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0476"},{"issue":"1","key":"17","first-page":"51","volume":"50","year":"2006","journal-title":"European Journal of Histochemistry"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2008.00591.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00657.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2006.00682.x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1159\/000118032"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00696.x"},{"issue":"2","key":"23","first-page":"326","volume":"43","year":"2011","journal-title":"Micron"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.007260"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.06.006"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2006.00177.x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.11.003"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2007.00748.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2007.02.001"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2011.621508"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.12.003"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24092"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)81008-4"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-079x.2003.00092.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00614-4"},{"issue":"4","key":"36","first-page":"539","volume":"25","year":"2009","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.2174\/157015910792246236"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12010"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12162"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-1891(02)00212-4"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1006"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12168"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.2.487"},{"key":"44","first-page":"105","volume-title":"Catalase","year":"1982"},{"issue":"20","key":"45","first-page":"6186","volume":"251","year":"1976","journal-title":"The Journal of Biological Chemistry"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(79)81346-0"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(77)90043-4"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-003-0160-8"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.2.1009"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2005.08.005"},{"issue":"2","key":"51","first-page":"105","volume":"13","year":"2010","journal-title":"Archives of Iranian Medicine"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.05.018"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12056"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789x.2010.00756.x"},{"issue":"1","key":"55","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0022-5347(17)43042-4","volume":"138","year":"1987","journal-title":"Journal of Urology"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-4-1737"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-100"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-2952(98)00370-0"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(05)67685-9"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1593\/neo.06739"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1002\/pros.1115"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2007.05.007"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21455"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.3109\/10409239509083491"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.05.009"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2007.22.2.67"},{"issue":"7","key":"67","first-page":"2074","volume":"119","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.68"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.1.105"},{"issue":"3","key":"70","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/j.1939-4640.2002.tb02236.x","volume":"23","year":"2002","journal-title":"Journal of Andrology"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00709-8"},{"issue":"5","key":"72","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1242\/jcs.108.5.2017","volume":"108","year":"1995","journal-title":"Journal of Cell Science"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038565"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.4.1102"},{"key":"75","first-page":"157","volume":"53","year":"1998","journal-title":"Journal of reproduction and fertility. Supplement"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220705"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.4161\/derm.22344"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.106450"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-012-9396-1"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/614579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/614579.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/614579.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T21:05:15Z","timestamp":1717880715000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/omcl\/2015\/614579\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":79,"alternative-id":["614579","614579"],"URL":"https:\/\/doi.org\/10.1155\/2015\/614579","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}