{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:17:54Z","timestamp":1740140274807,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RG 1435-072"],"award-info":[{"award-number":["RG 1435-072"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Quetiapine is an atypical antipsychotic, used clinically in the treatment of schizophrenia, acute mania in bipolar disorders, and bipolar depression in adults. In this study, the effect of green tea extracts (GTE) on the pharmacokinetics of quetiapine (substrate of CYP3A4) was investigated in rats. Male Wistar albino rats received GTE (175\u2009mg\/kg) or saline (control) by oral gavage for 7 days before a single intragastric administration of 25\u2009mg\/kg quetiapine. Plasma concentrations of quetiapine were measured up to 12\u2009h after its administration by a validated ultraperformance liquid chromatography-tandem mass spectroscopy. Pretreatment with GTE produced significant reductions in the maximum plasma concentration and area under the curve of quetiapine by 45% and 35%, respectively, compared to quetiapine alone. However, GTE did not produce significant change in elimination half-life and oral clearance of quetiapine. This study concluded that GTE may decrease the bioavailability of quetiapine when coadministered.<\/jats:p>","DOI":"10.1155\/2015\/615285","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T16:02:15Z","timestamp":1422547335000},"page":"1-4","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-5913","authenticated-orcid":true,"given":"Essam","family":"Ezzeldin","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Bioavailability Laboratory, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousif A.","family":"Asiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-5600","authenticated-orcid":true,"given":"Muzaffar","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Bioavailability Laboratory, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.06.011"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2641"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2009.05.005"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.09.011"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2006.08.004"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-009-0411-z"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114509991218"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-4889(01)00175-6"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-12-RG-101"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.036640"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.04.001"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-931537"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.033"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-13-NT-006"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.07.003"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.19.280"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e32832d6834"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.03.033"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1211\/0022357055687"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2008.8645"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/yic.0b013e32834e4c56"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.181"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e3181f15849"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200140070-00003"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200102000-00016"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/hup.869"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02507.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.55"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.045237"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/615285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/615285.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/615285.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T18:31:13Z","timestamp":1469644273000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2015\/615285\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":29,"alternative-id":["615285","615285"],"URL":"https:\/\/doi.org\/10.1155\/2015\/615285","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2015]]}}}