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Macrophage galactose-type lectin 1 (MGL1) recognizes glycoconjugates expressing Lewis X structures which contain galactose residues, and it is selectively expressed on immature DCs and macrophages. Helminth parasites contain large amounts of glycosylated components, which play a role in the immune regulation induced by such infections. Macrophages from MGL1<jats:sup>\u2212\/\u2212<\/jats:sup>mice showed less binding ability toward parasite antigens than their wild-type (WT) counterparts. Exposure of WT macrophages to<jats:italic>T. crassiceps<\/jats:italic>antigens triggered tyrosine phosphorylation signaling activity, which was diminished in MGL1<jats:sup>\u2212\/\u2212<\/jats:sup>macrophages. Following<jats:italic>T. crassiceps<\/jats:italic>infection, MGL1<jats:sup>\u2212\/\u2212<\/jats:sup>mice failed to produce significant levels of inflammatory cytokines early in the infection compared to WT mice. In contrast, MGL1<jats:sup>\u2212\/\u2212<\/jats:sup>mice developed a Th2-dominant immune response that was associated with significantly higher parasite loads, whereas WT mice were resistant. Flow cytometry and RT-PCR analyses showed overexpression of the mannose receptors, IL-4R<jats:italic>\u03b1<\/jats:italic>, PDL2, arginase-1, Ym1, and RELM-<jats:italic>\u03b1<\/jats:italic>on MGL1<jats:sup>\u2212\/\u2212<\/jats:sup>macrophages. These studies indicate that MGL1 is involved in<jats:italic>T. crassiceps<\/jats:italic>recognition and subsequent innate immune activation and resistance.<\/jats:p>","DOI":"10.1155\/2015\/615865","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T21:01:00Z","timestamp":1421355660000},"page":"1-16","source":"Crossref","is-referenced-by-count":11,"title":["The Macrophage Galactose-Type Lectin-1 (MGL1) Recognizes<i>Taenia crassiceps<\/i>Antigens, Triggers Intracellular Signaling, and Is Critical for Resistance to This Infection"],"prefix":"10.1155","volume":"2015","author":[{"given":"Daniel","family":"Montero-Barrera","sequence":"first","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Avenue de los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, 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