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However, there are no studies about the anxiolytic and antidepressant activities of<jats:italic>Camellia euphlebia<\/jats:italic>. This study evaluated the anxiolytic and antidepressant activities of the aqueous extract from<jats:italic>Camellia euphlebia<\/jats:italic>(CEE) in mice. We found that administration of 400\u2009mg\/kg CEE or 20\u2009mg\/kg fluoxetine for 7 days significantly reduced the immobility time in both TST and FST. Oral administration of 100\u2009mg\/kg extract or 4\u2009mg\/kg diazepam for 7 days significantly increased the percentage of time spent and the number of entries into the open arms of the EPMT. In addition, the time spent by mice in the illuminated side of the LDBT was increased. Furthermore, pretreatment with 400\u2009mg\/kg CEE for 7 days significantly elevated the level of 5-HT and DA in the whole brain of mice. These results provide support for the potential anxiolytic and antidepressant activity of<jats:italic>Camellia euphlebia<\/jats:italic>and contribute towards validation of the traditional use of<jats:italic>Camellia euphlebia<\/jats:italic>in the treatment of emotional disorders.<\/jats:p>","DOI":"10.1155\/2015\/618409","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T21:08:33Z","timestamp":1444943313000},"page":"1-8","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract from<i>Camellia euphlebia<\/i>Merr. ex Sealy in Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Dongye","family":"He","sequence":"first","affiliation":[{"name":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China"},{"name":"Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xitao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China"},{"name":"Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxing","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China"},{"name":"Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China"},{"name":"Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China"},{"name":"Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuying","family":"Li","sequence":"additional","affiliation":[{"name":"Dalian SEM Bio-Engineering Technology Co. 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