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To explore the possible role of MIF and Th17 cells in the thyroid\u2010specific autoimmune damage of Hashimoto\u2019s thyroiditis (HT). <jats:italic>Material and Methods<\/jats:italic>. We enrolled 40 HT patients and 30 healthy controls and divided HT patients into euthyroid subset (<jats:italic>n<\/jats:italic> = 22) and subclinical or overt hypothyroidism subset (<jats:italic>n<\/jats:italic> = 18). The percentages of Th17 cells and expressions of MIF, interleukin 17A (IL\u201017A) mRNA in PBMCs, as well as serum concentrations of MIF, and IL\u201017A, and thyroid functions, and thyroid\u2010specific autoantibodies (TPOAb, TgAb) were detected by flow cytometry, real\u2010time RT\u2010PCR, ELISA, and ECLIA in all subjects. <jats:italic>Results<\/jats:italic>. MIF mRNA, IL\u201017A mRNA expressions and Th17 cells percentages, serum MIF, and IL\u201017A protein levels were all significantly higher in HT patients, even in euthyroid subgroup. Additionally, the differences became more obvious in dysfunction subgroup. Importantly, both MIF levels and Th17 cells percentage were positively correlated with serum TPOAb, TgAb, and thyrotropin (TSH) levels in HT patients. <jats:italic>Conclusions<\/jats:italic>. These data suggest that MIF and Th17 cells increased dynamically and positively correlated with the markers of thyroid autoimmune damage, which indicated that interaction between MIF and Th17 cells may participate in the pathogenesis and development of thyroid\u2010specific autoimmunity in HT.<\/jats:p>","DOI":"10.1155\/2015\/621072","type":"journal-article","created":{"date-parts":[[2015,3,15]],"date-time":"2015-03-15T21:01:16Z","timestamp":1426453276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Macrophage Migration Inhibitory Factor Interacting with Th17 Cells May Be Involved in the Pathogenesis of Autoimmune Damage in Hashimoto\u2019s Thyroiditis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Haibo","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoujun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,15]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9703-2"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr030"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2291"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje-11-1041"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra021194"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.016"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa054022"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.153.3731.80"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06735.x"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker268"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x2012007500152"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092849"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0407-345"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.004"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02879.x"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m112.367532"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.007"},{"key":"e_1_2_10_19_2","volume-title":"Methods for Measuring Iodine in Urine","author":"Dunn J. 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