{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:08:41Z","timestamp":1790842121098,"version":"4.1.0"},"reference-count":34,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Invasive tumours in Nelson\u2019s syndrome need aggressive therapy. Recent reports have documented the efficacy of temozolomide (TMZ) in the treatment of adenomas resistant to conventional management.<jats:italic>Objective<\/jats:italic>. The review of the literature concerning TMZ treatment of atypical corticotroph adenomas and a case study of 56-year-old woman who developed Nelson\u2019s syndrome.<jats:italic>Treatment Proceeding<\/jats:italic>. The patient with Cushing\u2019s disease underwent transsphenoidal adenomectomy followed by a 27-month-long period of remission. Due to a regrowth of the tumor, she underwent two reoperations followed by stereotactic radiotherapy. Because of treatment failures, bilateral adrenalectomy was performed. Then she developed Nelson\u2019s syndrome. A fourth transsphenoidal adenomectomy was performed, but there was a rapid recurrence. Five months later, she underwent a right frontotemporal craniotomy. Due to a rapid regrowth of the tumour, the patient did not receive gamma-knife therapy and was treated with cabergoline and somatostatin analogue for some time. Only TMZ therapy resulted in marked clinical, biochemical, and radiological improvement. To date, this is the first case of invasive corticotroph adenoma in Nelson\u2019s syndrome treated with temozolomide in Poland.<jats:italic>Conclusion<\/jats:italic>. In our opinion, temozolomide can be an effective treatment option of invasive adenomas in Nelson\u2019s syndrome.<\/jats:p>","DOI":"10.1155\/2015\/623092","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T21:03:27Z","timestamp":1435611807000},"page":"1-8","source":"Crossref","is-referenced-by-count":20,"title":["Temozolomide-Induced Shrinkage of Invasive Pituitary Adenoma in Patient with Nelson\u2019s Syndrome: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2015","author":[{"given":"Maria","family":"Kurowska","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Medical University of Lublin, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Medical University of Lublin, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Zieli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Military Medical Institute, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Malicka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Medical University of Lublin, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy S.","family":"Tarach","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Medical University of Lublin, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Maksymowicz","sequence":"additional","affiliation":[{"name":"Department of Pathology, M. 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