{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:04:29Z","timestamp":1760853869500},"reference-count":29,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. CD30<jats:sup>+<\/jats:sup>lymphoproliferative disorder is a rare variant of cutaneous T-cell lymphoma. Sustained complete response following first-line treatments is rare. This retrospective review evaluates the response of refractory or recurrent lesions to palliative radiation therapy.<jats:italic>Methods<\/jats:italic>. The records of 6 patients with 12 lesions, treated with radiation therapy, were reviewed. All patients received previous first-line treatments. Patients with clinical and pathological evidence of symptomatic CD30<jats:sup>+<\/jats:sup>lymphoproliferative disorder, with no history of other cutaneous T-cell lymphoma variants, and with no prior radiation therapy to the index site were included.<jats:italic>Results<\/jats:italic>. The median age of patients was 50.5 years (range, 15\u201383 years). Median size of the treated lesions was 2.5\u2009cm (range, 2\u20137\u2009cm). Four sites were treated with a single fraction of 750\u2013800\u2009cGy (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:math>) and 8 sites were treated with 4000\u20134500\u2009cGy in 200\u2013250\u2009cGy fractions (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:math>). Radiation therapy was administered with electrons and bolus. Median follow-up was 113 months (range, 16\u2013147 months). For all sites, there was 100% complete response with acute grade 1-2 dermatitis.<jats:italic>Conclusions<\/jats:italic>. For recurrent and symptomatic radiation-na\u00efve CD30<jats:sup>+<\/jats:sup>lymphoproliferative disorder lesions, palliative radiation therapy shows excellent response. A single fraction of 750\u2013800\u2009cGy is as effective as a multifractionated course and more convenient.<\/jats:p>","DOI":"10.1155\/2015\/629587","type":"journal-article","created":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T21:07:09Z","timestamp":1443992829000},"page":"1-10","source":"Crossref","is-referenced-by-count":8,"title":["Single-Fraction Radiotherapy for CD30<sup>+<\/sup>Lymphoproliferative Disorders"],"prefix":"10.1155","volume":"2015","author":[{"given":"Michelle S.","family":"Gentile","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Estela","family":"Martinez-Escala","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarita O.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Loyola University, Chicago, IL 60153, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Guitart","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Rosen","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Kuzel","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat B.","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Northwestern University, Robert H. 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