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IL\u20101 is a potent proinflammatory cytokine and is involved in various inflammatory diseases. Other IL\u20101 family ligands are critical for the development of diverse diseases, including inflammatory and allergic diseases. Only IL\u20101Ra possesses the leader peptide required for secretion from cells, and many ligands require posttranslational processing for activation. Some require inflammasome\u2010mediated processing for activation and release, whereas others serve as alarmins and are released following cell membrane rupture, for example, by pyroptosis or necroptosis. Thus, each ligand has the proper molecular process to exert its own biological functions. In this review, we will give a brief introduction to the IL\u20101 family cytokines and discuss their pivotal roles in the development of various liver diseases in association with immune responses. For example, an excess of IL\u201033 causes liver fibrosis in mice via activation and expansion of group 2 innate lymphoid cells to produce type 2 cytokines, resulting in cell conversion into pro\u2010fibrotic M2 macrophages. Finally, we will discuss the importance of IL\u20101 family cytokine\u2010mediated molecular and cellular networks in the development of acute and chronic liver diseases.<\/jats:p>","DOI":"10.1155\/2015\/630265","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T21:58:00Z","timestamp":1444946280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Interleukin\u20101 Family Cytokines in Liver 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