{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:57:44Z","timestamp":1777193864521,"version":"3.51.4"},"reference-count":44,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Anti-M\u00fcllerian hormone receptor, type II (AMHR2), is a differentiation protein expressed in 90% of primary epithelial ovarian carcinomas (EOCs), the most deadly gynecologic malignancy. We propose that AMHR2 may serve as a useful target for vaccination against EOC. To this end, we generated the recombinant 399-amino acid cytoplasmic domain of mouse AMHR2 (AMHR2-CD) and tested its efficacy as a vaccine target in inhibiting growth of the ID8 transplantable EOC cell line in C57BL\/6 mice and in preventing growth of autochthonous EOCs that occur spontaneously in transgenic mice. We found that AMHR2-CD immunization of C57BL\/6 females induced a prominent antigen-specific proinflammatory CD4+ T cell response that resulted in a mild transient autoimmune oophoritis that resolved rapidly with no detectable lingering adverse effects on ovarian function. AMHR2-CD vaccination significantly inhibited ID8 tumor growth when administered either prophylactically or therapeutically, and protection against EOC growth was passively transferred into naive recipients with AMHR2-CD-primed CD4+ T cells but not with primed B cells. In addition, prophylactic AMHR2-CD vaccination of TgMISIIR-TAg transgenic mice significantly inhibited growth of autochthonous EOCs and provided a 41.7% increase in mean overall survival. We conclude that AMHR2-CD vaccination provides effective immunotherapy of EOC with relatively benign autoimmune complications.<\/jats:p>","DOI":"10.1155\/2015\/630287","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T21:01:57Z","timestamp":1446757317000},"page":"1-13","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-M\u00fcllerian Hormone Receptor II"],"prefix":"10.1155","volume":"2015","author":[{"given":"Cagri","family":"Sakalar","sequence":"first","affiliation":[{"name":"Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"},{"name":"School of Medicine, Department of Medical Biology, Genome and Stem Cell Research Center, Erciyes University, 38039 Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suparna","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Department of Biology, Cleveland State University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cengiz Z.","family":"Altuntas","sequence":"additional","affiliation":[{"name":"Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"},{"name":"North American University, Texas Institute of Biotechnology, Education, and Research, 10555 Stella Link Road, No. 102, Houston, TX 77025, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritika","family":"Jaini","sequence":"additional","affiliation":[{"name":"Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Department of Biology, Cleveland State University, Cleveland, OH, USA"},{"name":"Western Reserve Academy, Hudson, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathyamangla V. 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