{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:23:01Z","timestamp":1793294581825,"version":"4.5.0"},"reference-count":20,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the effectiveness and safety of the Ologen as an aid for trabeculectomy performed for primary open-angle glaucoma compared with mitomycin C.<jats:italic>Methods<\/jats:italic>. In this prospective, randomized, parallel assignment, comparative study, 31 eyes of 21 primary open-angle glaucoma patients were allocated for trabeculectomy with the Ologen implant; another 32 eyes of 23 patients were treated with trabeculectomy augmented with mitomycin C. The patients were followed up for 5 years and evaluated for intraocular pressure, rate of success, status of the bleb, and adverse events.<jats:italic>Result<\/jats:italic>. The mean postoperative intraocular pressure was statistically different at 3\u2009m, 6\u2009m, 1\u2009y, 3\u2009y, and 5\u2009y follow-up. The rates of both complete success<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.017<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>and overall success<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.031<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>in the Ologen group were significantly higher than those in the mitomycin C group. The difference of the bleb extent and vascularity was statistically significant in both groups. There was no significant difference in postoperative complication.<jats:italic>Conclusions<\/jats:italic>. Ologen provides higher rates of surgical success compared with mitomycin C for patients with primary open-angle glaucoma undergoing trabeculectomy. It may be a new, safe, simple, and effective therapeutic approach for treating primary open-angle glaucoma.<\/jats:p>","DOI":"10.1155\/2015\/637537","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T17:04:51Z","timestamp":1432055091000},"page":"1-7","source":"Crossref","is-referenced-by-count":31,"title":["Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years"],"prefix":"10.1155","volume":"2015","author":[{"given":"Fei","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2011.07.005"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2004.00752.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063591"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1990.6.175"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181659e56"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(01)00691-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0744-9"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1586\/17469899.3.6.613"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0378"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.106"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01753.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.109520"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0120"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.035"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(01)00873-9"},{"issue":"9","key":"16","first-page":"1848","volume":"31","year":"1990","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"10","key":"17","first-page":"1551","volume":"91","year":"2008","journal-title":"Journal of the Medical Association of Thailand"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(03)00038-9"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.219"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085782"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2015\/637537.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2015\/637537.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2015\/637537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T16:47:02Z","timestamp":1469638022000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/joph\/2015\/637537\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":20,"alternative-id":["637537","637537"],"URL":"https:\/\/doi.org\/10.1155\/2015\/637537","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}