{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:08:33Z","timestamp":1773857313622,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Secondary hyperparathyroidism increases morbidity and mortality in hemodialysis patients. The Kidney Disease Outcomes Quality Initiative Guidelines recommend parathyroidectomy for patients with chronic kidney disease and parathyroid hormone concentrations exceeding 800\u2009pg\/mL; however, this concentration represents an arbitrary cut-off value. The present study was conducted to identify factors influencing mortality in hemodialysis patients with parathyroid hormone concentrations exceeding 800\u2009pg\/mL and to evaluate the effects of parathyroidectomy on outcome for these patients. Two hundred twenty-one hemodialysis patients with parathyroid hormone concentrations &gt; 800\u2009pg\/mL from July 2004 to June 2010 were identified. 21.1% of patients (<jats:italic>n<\/jats:italic>= 60) received parathyroidectomy and 14.9% of patients (<jats:italic>n<\/jats:italic>= 33) died during a mean follow-up of 36 months. Patients with parathyroidectomy were found to have lower all-cause mortality (adjusted hazard ratio [aHR]: 0.34). Other independent predictors included age \u2265 65 years (aHR: 2.11) and diabetes mellitus (aHR: 3.80). For cardiovascular mortality, parathyroidectomy was associated with lower mortality (HR = 0.31) but with a marginal statistical significance (<jats:italic>p<\/jats:italic>= 0.061). In multivariate analysis, diabetes was the only significant predictor (aHR: 3.14). It is concluded that, for hemodialysis patients with parathyroid hormone concentrations greater than 800\u2009pg\/mL, parathyroidectomy is associated with reduced all-cause mortality.<\/jats:p>","DOI":"10.1155\/2015\/639587","type":"journal-article","created":{"date-parts":[[2015,5,3]],"date-time":"2015-05-03T21:05:17Z","timestamp":1430687117000},"page":"1-7","source":"Crossref","is-referenced-by-count":20,"title":["Parathyroidectomy Is Associated with Reduced Mortality in Hemodialysis Patients with Secondary Hyperparathyroidism"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-7966","authenticated-orcid":true,"given":"Tsung-Liang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, 539 Jhongsiao Road, Chiayi 600, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peir-Haur","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, 539 Jhongsiao Road, Chiayi 600, Taiwan"},{"name":"Department of Applied Life Science and Health, Chia Nan University of Pharmacy and Science, No. 60, Section 1, Erren Road, Rende District, Tainan 71710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ing-Ching","family":"Jong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, 539 Jhongsiao Road, Chiayi 600, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Yen","family":"Hiao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, 539 Jhongsiao Road, Chiayi 600, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh-Han","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, 539 Jhongsiao Road, Chiayi 600, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Chun","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, 539 Jhongsiao Road, Chiayi 600, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"How-Ran","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan"},{"name":"Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 704, 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