{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:49:32Z","timestamp":1764251372207,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Meniere\u2019s disease (MD) is an inner ear disorder characterized by episodic vertigo, ear fullness, and hearing loss; usually vertigo attacks cluster in specific period. We studied in MD patients the circulating levels of chromogranin A (CgA) and vasostatin-1 (VS-1), secreted by the neuroendocrine system and involved in the regulation of the endothelial barrier function.<jats:italic>Methods<\/jats:italic>. Serum levels were assessed in 37 MD patients and 36 controls. The ratio between VS-1 and CgA was calculated.<jats:italic>Results<\/jats:italic>. CgA was increased in patients compared to controls (1.46 versus 0.67\u2009nM,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) while no difference was detected for VS-1 (0.41 versus 0.39, resp.). CgA levels in patients positively correlated with the frequency of vertigo spells in the previous four weeks (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>) and negatively with the time in days from the last vertigo attack (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.018<\/mml:mn><\/mml:math>). Furthermore, the VS-1\/CgA ratio negatively correlated with the frequency of vertigo spells (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.029<\/mml:mn><\/mml:math>) and positively correlated with the time from the last attack (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. The results indicate that variations of CgA levels, but not of VS-1, occur in the blood of patients with active MD, depending on the frequency of vertigo spells and the time from the last crisis.<\/jats:p>","DOI":"10.1155\/2015\/643420","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T18:19:26Z","timestamp":1429813166000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Altered Chromogranin A Circulating Levels in Meniere\u2019s Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Roberto","family":"Teggi","sequence":"first","affiliation":[{"name":"ENT Division, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Trimarchi","sequence":"additional","affiliation":[{"name":"ENT Division, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimma","family":"Bianco","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Division of Regenerative Medicine, Stem Cells & Gene Therapy, San Raffaele Scientific Institute, Universit\u00e0 Vita-Salute San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bussi","sequence":"additional","affiliation":[{"name":"ENT Division, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0893-6191","authenticated-orcid":true,"given":"Angelo","family":"Corti","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology, San Raffaele Scientific Institute, Milan, 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