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Furthermore, ROS have a major role in carcinogenesis and disease progression in the myeloproliferative neoplasms (MPNs), where the malignant clone itself produces excess of ROS thereby creating a vicious self\u2010perpetuating circle in which ROS activate proinflammatory pathways (NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B) which in turn create more ROS. Targeting ROS may be a therapeutic option, which could possibly prevent genomic instability and ultimately myelofibrotic and leukemic transformation. In regard to the potent efficacy of the ROS\u2010scavenger N\u2010acetyl\u2010cysteine (NAC) in decreasing ROS levels, it is intriguing to consider if NAC treatment might benefit patients with MPN. The encouraging results from studies in cystic fibrosis, systemic lupus erythematosus, and chronic obstructive pulmonary disease warrant such studies. In addition, the antioxidative potential of the widely used agents, interferon\u2010alpha2, statins, and JAK inhibitors, should be investigated as well. A combinatorial approach using old agents with anticancer properties together with novel JAK1\/2 inhibitors may open a new era for patients with MPNs, the outlook not only being \u201cminimal residual disease\u201d and potential cure but also a marked improvement in inflammation\u2010mediated comorbidities.\n                  <\/jats:p>","DOI":"10.1155\/2015\/648090","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T19:17:26Z","timestamp":1444677446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms"],"prefix":"10.1155","volume":"2015","author":[{"given":"Mads Emil","family":"Bj\u00f8rn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans 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