{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:27:20Z","timestamp":1790011640480,"version":"4.0.1"},"reference-count":28,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The present study was designed to investigate the effect of<jats:italic>Agaricus brasiliensis<\/jats:italic>extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of<jats:italic>in vitro<\/jats:italic>bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>O<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>\/SOD, level of NF-<jats:italic>\u03ba<\/jats:italic>B protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that<jats:italic>Agaricus brasiliensis<\/jats:italic>extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.<\/jats:p>","DOI":"10.1155\/2015\/651218","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T23:27:29Z","timestamp":1427326049000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Therapeutic Effect of<i>Agaricus brasiliensis<\/i>on Phenylhydrazine-Induced Neonatal Jaundice in Rats"],"prefix":"10.1155","volume":"2015","author":[{"given":"Lan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Second Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yuan","sequence":"additional","affiliation":[{"name":"Xi\u2019an Central Hospital, Xi\u2019an 710003, 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