{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:00:20Z","timestamp":1768798820478,"version":"3.49.0"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The goal of this study was to evaluate the actual anatomical and dosimetric changes of parotid glands in nasopharyngeal carcinoma patients during intensity modulated radiation therapy. With helical tomotherapy, its planning system, and adaptive software, weekly anatomical and dosimetric changes of parotid glands in 35 NPC patients were evaluated. Interweekly parotid volume varied significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:math>). The rate of volume change reached the highest level at the 16th fraction. The average<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>V<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>increased by 32.2 (left) and 28.6 (right), and the average<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>D<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>50<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>increased by 33.9 (left) and 24.93 (right), respectively. Repeat data comparison indicated that the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mi>V<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:msub><mml:mrow><mml:mi>D<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>50<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>varied significantly among different fractions (both with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.000<\/mml:mn><\/mml:math>). The variation of parotid volume was inversely correlated with that of the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:msub><mml:mrow><mml:mi>V<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:msub><mml:mrow><mml:mi>D<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>50<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>(both with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.000<\/mml:mn><\/mml:math>). In conclusion, parotid volume and actual dose vary significantly in NPC patients during IMRT. Replanning at the end of the fourth week of IMRT may have clinical benefits.<\/jats:p>","DOI":"10.1155\/2015\/670327","type":"journal-article","created":{"date-parts":[[2015,2,22]],"date-time":"2015-02-22T16:01:19Z","timestamp":1424620879000},"page":"1-6","source":"Crossref","is-referenced-by-count":16,"title":["Actual Anatomical and Dosimetric Changes of Parotid Glands in Nasopharyngeal Carcinoma Patients during Intensity Modulated Radiation Therapy"],"prefix":"10.1155","volume":"2015","author":[{"given":"Gang","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Beijing 100142, China"},{"name":"Department of Radiation Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou-Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hainan Branch of Chinese PLA General Hospital, Haitang Bay, Sanya 572000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Chun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China"},{"name":"Department of Radiation Oncology, Hainan Branch of Chinese PLA General Hospital, Haitang Bay, Sanya 572000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Lin","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, 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