{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:12:10Z","timestamp":1774869130849,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>There are many reports that show different thyroid abnormalities in schizophrenia without clear establishment of their role in etiology and treatment outcome of schizophrenia. Among these reports, there are only a few that consider a role for thyroid hormones as augmenting agents in the treatment with antipsychotic drugs. This case report outlines symptom subsidence of a patient with clozapine refractory paranoid schizophrenia and normal thyroid function who added levothyroxine to clozapine and found that symptoms of psychosis returned once levothyroxine was discontinued. Although this observation needs to be confirmed in controlled clinical trials, we aimed to discuss possible hypothesized mechanisms underlying this observation.<\/jats:p>","DOI":"10.1155\/2015\/678040","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T17:06:50Z","timestamp":1431364010000},"page":"1-4","source":"Crossref","is-referenced-by-count":4,"title":["Levothyroxine Augmentation in Clozapine Resistant Schizophrenia: A Case Report and Review"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ruohollah","family":"Seddigh","sequence":"first","affiliation":[{"name":"Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Azarnik","sequence":"additional","affiliation":[{"name":"Shahid Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-7153","authenticated-orcid":true,"given":"Amir-Abbas","family":"Keshavarz-Akhlaghi","sequence":"additional","affiliation":[{"name":"Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3097-6"},{"key":"2","year":"2007"},{"issue":"3","key":"3","first-page":"121","volume":"7","year":"2010","journal-title":"Clinical Neuropsychiatry"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/569147"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2005.10.001"},{"key":"6","first-page":"75","volume-title":"Enhancement of antipsychotic effect of chlorpromazine with L-triiodothyronine","year":"1974"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s0924-977x(13)70724-7"},{"issue":"12, article 543","key":"8","volume":"55","year":"1994","journal-title":"Journal of Clinical Psychiatry"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/23.4.663"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.12.1744"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr004"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"issue":"5","key":"14","first-page":"641","volume":"31","year":"2002","journal-title":"Annals of the Academy of Medicine"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/s0924-9338(11)73219-9"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0920-9964(99)00187-5"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.06.008"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0278-5846(01)00311-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3109\/00048679409080785"},{"issue":"7","key":"20","first-page":"1045","volume":"75","year":"1975","journal-title":"Zhurnal Nevrologii i Psikhiatrii imeni S.S. 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