{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:51Z","timestamp":1777581351496,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["07-091\u20133-020"],"award-info":[{"award-number":["07-091\u20133-020"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS).<jats:italic>Methods<\/jats:italic>. We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (&lt;50%)) and group B (with significant stenosis (\u226550%)).<jats:italic>Results<\/jats:italic>. Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44\u2009mM,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.026<\/mml:mn><\/mml:math>) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36\u2009mM,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30\u20130.92),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.038<\/mml:mn><\/mml:math>, among patients with significant stenosis.<jats:italic>Conclusions<\/jats:italic>. Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.<\/jats:p>","DOI":"10.1155\/2015\/678924","type":"journal-article","created":{"date-parts":[[2015,3,8]],"date-time":"2015-03-08T17:04:10Z","timestamp":1425834250000},"page":"1-12","source":"Crossref","is-referenced-by-count":19,"title":["The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients"],"prefix":"10.1155","volume":"2015","author":[{"given":"Nasser M.","family":"Rizk","sequence":"first","affiliation":[{"name":"Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"El-Menyar","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Ahmed Maher Teaching Hospital, Cairo, Egypt"},{"name":"Clinical Medicine, Weill Cornell Medical School, P.O. Box 24144, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-0570","authenticated-orcid":true,"given":"Huda","family":"Egue","sequence":"additional","affiliation":[{"name":"Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-631X","authenticated-orcid":true,"given":"Idil","family":"Souleman Wais","sequence":"additional","affiliation":[{"name":"Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hissa","family":"Mohamed Baluli","sequence":"additional","affiliation":[{"name":"Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Alali","sequence":"additional","affiliation":[{"name":"Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fathi","family":"Farag","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Al-Emadi Hospital, P.O. Box 5804, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-8763","authenticated-orcid":true,"given":"Noura","family":"Younes","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Department, Hamad Medical Corporation (HMC), P.O. Box 3050, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jassim","family":"Al Suwaidi","sequence":"additional","affiliation":[{"name":"Cardiology Department, Heart Hospital, Hamad Medical Corporation (HMC), P.O. 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