{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:45:20Z","timestamp":1790232320785,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Pediatric autoimmune hepatitis (AIH) patients present hypergammaglobulinemia, periportal CD8<jats:sup>+<\/jats:sup>cytotoxic T cell infiltration, and cirrhosis. Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1. We previously detected increased IgE serum levels and sought to compare clinical and histological features according to IgE levels in AIH (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>74<\/mml:mn><\/mml:math>, ages 1\u201314 years) patients. Additionally, we typed 117 patients and 227 controls for functional polymorphisms of IL4, IL13, IL5, and IL4RA genes involved in IgE switching and eosinophil maturation that might contribute to overall genetic susceptibility to AIH. Serum IgE levels were high in 55% of AIH-1, but only in 12% of AIH-2 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>) patients. Liver IgE was present in 91.3% of AIH-1 patients. The A alleles at both IL13 rs20541 and IL4RA rs1805011 were associated with AIH-1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.024<\/mml:mn><\/mml:math>, OR = 1.55 and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>, OR = 2.15, resp.). Furthermore, individuals presenting homozygosis for the A allele at IL4RA rs1805011 and HLA-DRB1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mrow><mml:mn>03<\/mml:mn><\/mml:mrow><mml:mrow><mml:mi>\u2217<\/mml:mi><\/mml:mrow><\/mml:mrow><\/mml:math>and\/or<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mrow><mml:mn>13<\/mml:mn><\/mml:mrow><mml:mrow><mml:mi>\u2217<\/mml:mi><\/mml:mrow><\/mml:mrow><\/mml:math>allele had sixfold greater risk to develop the disease (OR = 14.00,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The novel association suggests an additional role for IgE-linked immune response genes in the pathogenesis of AIH.<\/jats:p>","DOI":"10.1155\/2015\/679813","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T21:01:16Z","timestamp":1448571676000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes"],"prefix":"10.1155","volume":"2015","author":[{"given":"L\u00e9a Campos","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Medicina Laboratorial (LIM03), Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, 05403-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carla","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, 05652-900 S\u00e3o Paulo, SP, Brazil"},{"name":"Instituto de 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