{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:57:12Z","timestamp":1782698232865,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006096","name":"Shiraz Transplant Research Center, Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006096","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hazrat Fatima"},{"name":"Barij Essence Company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Effect of<jats:italic>Zataria multiflora<\/jats:italic>on bacterial vaginosis and<jats:italic>Trichomonas vaginalis<\/jats:italic>is shown in vivo and in vitro. We compare the effectiveness of<jats:italic>Zataria multiflora<\/jats:italic>cream and oral metronidazole pill on results of treatment for vaginal infections including<jats:italic>Trichomonas<\/jats:italic>and bacterial vaginosis; these infections occur simultaneously. The study included 420 women with bacterial vaginosis,<jats:italic>Trichomonas vaginalis<\/jats:italic>, or both infections together, who were randomly divided into six groups. Criteria for diagnosis were wet smear and Gram stain. Vaginal<jats:italic>Zataria multiflora<\/jats:italic>cream and placebo pill were administered to the experiment groups; the control group received oral metronidazole pill and vaginal placebo cream. Comparison of the clinical symptoms showed no significant difference in all three vaginitis groups receiving metronidazole pill and vaginal<jats:italic>Zataria multiflora<\/jats:italic>cream. However, comparison of the wet smear test results was significant in patients with trichomoniasis and bacterial vaginosis associated with trichomoniasis in the two treatment groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). Vaginal<jats:italic>Zataria multiflora<\/jats:italic>cream had the same effect of oral metronidazole tablets in improving clinical symptoms of all three vaginitis groups, as well as the treatment for bacterial vaginosis. It can be used as a drug for treatment of bacterial vaginosis and elimination of clinical symptoms of<jats:italic>Trichomonas<\/jats:italic>vaginitis.<\/jats:p>","DOI":"10.1155\/2015\/683640","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T17:02:16Z","timestamp":1437498136000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of the Effect of Vaginal<i>Zataria multiflora<\/i>Cream and Oral Metronidazole Pill on Results of Treatments for Vaginal Infections including Trichomoniasis and Bacterial Vaginosis in Women of Reproductive Age"],"prefix":"10.1155","volume":"2015","author":[{"given":"Khadijeh","family":"Abdali","sequence":"first","affiliation":[{"name":"Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz 7193613119, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Jahed","sequence":"additional","affiliation":[{"name":"Dezful Health Center, Dezful University of Medical Science, Dezful 7461715765, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedigheh","family":"Amooee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz 713451978, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Zarshenas","sequence":"additional","affiliation":[{"name":"Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz 7193613119, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Tabatabaee","sequence":"additional","affiliation":[{"name":"Department of Statistics, Health Faculty, Shiraz University of Medical Sciences, Shiraz 713451978, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Bekhradi","sequence":"additional","affiliation":[{"name":"Clinical Trials Department, Barij Essence Company, P.O. 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