{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:51:41Z","timestamp":1780051901181,"version":"3.53.1"},"reference-count":59,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Beh\u00e7et\u2019s disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma delta (<jats:italic>\u03b3\u03b4<\/jats:italic>) T cells are reported to have a role.<jats:italic>\u03b3\u03b4<\/jats:italic>T cells are atypical T cells, which represent a small proportion of total lymphocytes. They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells. These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and\/or maintaining the proinflammatory environment characteristic of the disease. Over the last 20 years there has been much interest in the role of<jats:italic>\u03b3\u03b4<\/jats:italic>T cells in BD. We review the literature and discuss the roles that<jats:italic>\u03b3\u03b4<\/jats:italic>T cells may play in BD pathogenesis.<\/jats:p>","DOI":"10.1155\/2015\/705831","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T23:16:51Z","timestamp":1444691811000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["Gamma Delta (<i>\u03b3\u03b4<\/i>) T Cells and Their Involvement in Beh\u00e7et\u2019s Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Md. 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