{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:24:10Z","timestamp":1784301850248,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Medical University of Bialystok, Poland","award":["123-50-723L"],"award-info":[{"award-number":["123-50-723L"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Since recent reports suggest that Hashimoto thyroiditis (HT) may be associated with IgG4-related disease, we aimed to find out whether the measurement of serum IgG4 allows for the identification of distinct types of HT, with different clinical, sonographic, and serologic characteristics.<jats:italic>Methods<\/jats:italic>. The group studied consisted of 53 patients with HT and 28 healthy individuals who underwent thyroid ultrasonography and body composition analysis. Serum concentrations of IgG4, TSH, anti-peroxidase antibodies (TPOAb), anti-TSH receptor antibodies, TNF-<jats:italic>\u03b1<\/jats:italic>, TGF-<jats:italic>\u03b2<\/jats:italic>1, Fas Ligand, TRAIL, and chemokines (CXCL9, CXCL11, and CXCL10) were measured by ELISA or radioimmunoassay.<jats:italic>Results<\/jats:italic>. The group with IgG4 level &gt;135\u2009IU\/ml accounted for 32.5% of the patients. The signs of fibrosis were present in 27.0% of the high-IgG4 patients and in 9.1% of the normal-IgG4 group. The patients with elevated IgG4 required higher doses of L-thyroxine and had significantly lower level of TPOAb (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mn>=<\/mml:mn><mml:mn>0.02<\/mml:mn><\/mml:math>) than the non-IgG4-HT individuals and higher TNF-<jats:italic>\u03b1<\/jats:italic>level in comparison with the controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mn>=<\/mml:mn><mml:mn>0.01<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Our results suggest that the measurement of serum IgG4 allows for an identification of patients with more rapid progression of HT, requiring higher doses of L-thyroxine. Low TPOAb level and the absence of coexisting autoimmune diseases may suggest distinct pathomechanism of this type of thyroiditis.<\/jats:p>","DOI":"10.1155\/2015\/706843","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T16:03:05Z","timestamp":1424102585000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["High Serum IgG4 Concentrations in Patients with Hashimoto\u2019s Thyroiditis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Anna","family":"Pop\u0142awska-Kita","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ko\u015bciuszko-Zdrodowska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 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