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Recent studies dealing with EPA and DHA have sparked highest interests because detailed molecular mechanisms had been documented with the identification of its receptor, G protein coupled receptor, and GPR120. In this review article, we have described clear evidences showing that n-3 PUFAs could reduce various<jats:italic>Helicobacter pylori<\/jats:italic>- (<jats:italic>H. pylori<\/jats:italic>-) associated gastric diseases and extended to play even cancer preventive outcomes including<jats:italic>H. pylori<\/jats:italic>-associated gastric cancer by influencing multiple targets, including proliferation, survival, angiogenesis, inflammation, and metastasis. Since our previous studies strongly concluded that nonantimicrobial dietary approach for reducing inflammation, for instance, application of phytoceuticals, probiotics, natural products including Korean red ginseng, and walnut plentiful of n-3 PUFAs, might be prerequisite step for preventing<jats:italic>H. pylori<\/jats:italic>-associated gastric cancer as well as facilitating the rejuvenation of precancerous atrophic gastritis, these beneficial lipids can restore or modify inflammation-associated lipid distortion and correction of altered lipid rafts to send right signaling to maintain healthy stomach even after chronic<jats:italic>H. pylori<\/jats:italic>infection.<\/jats:p>","DOI":"10.1155\/2015\/712363","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T02:29:02Z","timestamp":1438655342000},"page":"1-11","source":"Crossref","is-referenced-by-count":23,"title":["Omega-3 Polyunsaturated Fatty Acids Intake to Regulate<i>Helicobacter 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